The much-anticipated fixed-array, genome-wide SNP genotyping technologies make large-scale genome-wide association scans now possible for large numbers of subjects. In this paper we reconsider the problem (Satagopan and Elston [2003] Genet Epidemiol 25:149-157) of optimizing a two-stage genotyping design to deal with important new issues that are relevant when studies are expanded from candidat...

Approximately 4% of English-speaking children are affected by specific language impairment (SLI), a disorder in the development of language skills despite adequate opportunity and normal intelligence. Several studies have indicated the importance of genetic factors in SLI; a positive family history confers an increased risk of development, and concordance in monozygotic twins consistently excee...

It was already in the 18th century when the French surgeon LeDran first noted that breast cancer patients with spread of tumor cells to their axillary lymph nodes had a drastically worse prognosis than patients without spread (LeDran et al., ). Since then, metastatic spread of cancer cells to regional lymph nodes has been established as the most important prognostic factor in many types of canc...

BACKGROUND Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed. OBJECTIVE We aimed to assess the relationship between air pollution and preterm birth using 2008-2010 New York City (NYC) birth certificates linked to hospital records. METHODS We analyzed 258,294 singleton births with 22-42 completed weeks ges...

Published in the Scandinavian Journal of Laboratory Animal Science an international journal of laboratory animal science Introduction Over the last decades, a number of single genes with considerable effects on production and reproduction traits have been identified in livestock and laboratory animals. Mice were often proposed as model animals for human and livestock obesity as well as other ch...

In a recent paper published in PNAS (Golan et al. 2014), residual maximum likelihood (REML) seriously underestimated genetic variance explained by genomewide single nucleotide polymorphism when using a case-control design. It was concluded that Haseman–Elston regression (denoted as PCGC in their paper) should be used instead of REML. Their conclusions were based on results from simplified linka...

USCEPTIBILITY to audiogenic seizure in mice (HALL 1947; MILLER, GINSBURG and POTAS 1952) and rats (MAIER and GLASER 1940; MAIER 1943) has been shown to depend on the genotype of the animal. Different investigators have suggested different modes of inheritance for sound induced seizure including single-gene ( WITT and HALL 1949), two-gene ( GINSBURG and MILLER 1963) and polygenic modes of inheri...

The variation in survival of women with clinically similar breast cancers may lead to difficulty in clinical management so it is important to recognise factors which indicate the prognosis. Immunoperoxidase staining patterns of primary breast tumours using monoclonal antibody NCRC-11 have been shown to relate to overall survival (Ellis et al., 1985) but the results have not been reproducible in...

The problem treated in this research work is as follows: there are N mobile robots (unmanned ground vehicles) which pursue a moving target. The vehicles emanate from random positions in their motion plane. Each vehicle can be equipped with various sensors, such as odometric sensors, cameras and non-imaging sensors such as sonar, radar and thermal signature sensors. These vehicles can be conside...

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