BACKGROUND β-amyloid is regarded as a significant factor in Alzheimer's disease: but inefficient therapies based on this rationale suggests that additional signalling molecules or intermediary mechanisms must be involved in the actual initiation of the characteristic degeneration of neurons. One clue could be that acetylcholinesterase, also present in amyloid plaques, is aberrant in peripheral ...

ECG. Fine needle aspiration cytology, with immediate reporting in the outpatient diagnosis of breast cancer. Ann R Coll Surg Eng 1987;69:280-2. 3 Dixon JM, Clarke PJ, Crucioli V, Dehn TCB, Greenall M, Lee ECG. Reduction in biopsy rate in benign breast disease using fine needle aspiration cytology with immediate reporting. BrJ7 Surg 1987;74: 1014-6. 4 Lofgren M, Andersson I, Bondeson L, Lindholm...

We have tested acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from Anethum graveolens L. (organic fertilizer), two from Foeniculum vulgare Mill. collected at fully-mature and flowering stages (organic fertilizer), two from Melissa officinalis L. (cultivated using organic and chemical ferti...

The time-course covered by the original definition of scapulo-humeral periarthritis suggested by Duplay through the more recent term of subacromial impingement syndrome coined by Neer, follows the identification of the pathogenetic mechanisms leading to chronic subacromial impingement and degenerative tears of the rotator cuff. The Authors recall the functional-anatomic development evolution of...

1 Barrett DS, Cobb AG, Bentley G. Joint proprioception in normal, osteoarthritic and replaced knees. J Bone Joint Surg Br 1991; 73: 53–56. 2 Barrett DS. Proprioception and function after anterior cruciate reconstruction. J Bone Joint Surg Br 1991; 73: 833–37. 3 Skinner HD, Barrack RL, Cook SD. Age-related decline in proprioception. Clin Orthop 1984; 184: 208–01. A recent consensus statement fro...

One of the initial steps in the development of therapeutic agents is the identification of lead compounds that bind to the receptor or enzyme target of interest. Many analogs of these lead compounds are then synthesized to define the key recognition elements for maximal activity. In general, many compounds must be evaluated in both the lead identification and optimization steps. Increasing burd...

Malaria (vector: Anopheles gambiae) is a major infectious disease that kills about 1 million people each year. For the improvement of its treatment and vector control during the past decades, several issues such as high medicine cost, insecticide resistance, and lack of an effective vaccine have prevented adequate control of malaria. Additionally, the low selectivity of malaria vector insectici...

The 30 cases of essential pulmonary haemosiderosis hitherto published supply ample data to present not only the classical pattern of this disease but also its latent form. The condition mostly affects children; in adolescents (16 to 20 years of age) it was observed in two instances only (Waldenstrom, 1944; Walton and Williams, 1951) and the true nature of the adult cases reported by BorsosNacht...

Changes in redox status of gastric mucosa cells are the main pathogenic factor of gastric erosion and gastric ulcer development. Pro-oxidants can affect cell transcription activity via changes in redox-sensitive transcription factors. Egr-1 and Sp-1 may regulate the transcription of genes that are associated with the pathogenesis of gastric ulcer (growthfactors, cell cycle regulators, etc.). Th...