Accumulation of amethopterin by L1210 and Ehrlich ascites cells in miro was mediated by a slow, temperature-sensitive, and partly saturable process. The structural specificity of the proc ess could be measured by competition studies; differences were found between the two cell lines. At physiologic drug levels, i.e., those found in vivo during drug therapy, concentrativi uptake of amethopterin ...

Despite its wide use for qualitative as well as quantitative studies on tumor biology, the Ehrlich mouse ascites tumor has rarely been used for studies on the regression of cancer heterotransplants. The absence of stroma in this form of malignant growth should facilitate the quantita tive approach to the analysis of events occurring during the destruction of neoplastic heterotransplants. Accord...

Patient selection and survival after peritoneovenous shunting for nonmalignant ascites was assessed in 30 patients undergoing 44 peritoneovenous shunting procedures over a 5-year period. Indications for peritoneovenous shunting included refractory ascites alone, refractory ascites complicated by hepatorenal syndrome, and nonrefractory but recurrent ascites. Fifty-six percent of shunting procedu...

The purpose of the present work was to evaluate anticarcinogenic and cytotoxic potential of Hemidesmus indicus methanolic root extract (HiRe) against Ehrlich Ascites Tumor. The extract showed a significant in vitro cytotoxic activity against Ehrlich Ascites Tumor (EAT) cell line. IC50 value for EAT cell line was 274.83μg.The anticarcinogenic activity of the extract was determined by using EAT c...

OF4949-I and II inhibited aminopeptidase B from Ehrlich ascites carcinoma in a competitive way and the Ki value for both against L-arginine-beta-naphthylamide was 8 X 10(-9) M. Inhibition by I and II of various exopeptidases and endopeptidases was examined. OF4949-I and II both strongly inhibited leucine aminopeptidase and enkephalin-degrading aminopeptidase; I also inhibited enkephalinase B. T...

Annulate lamellae have been observed in eggs of marine invertebrates (1, 6, 12, 13, 18), rat spermatids (11, 17), crayfish spermatocytes (15), the amphibian pancreas (17), the adrenal cortex of the fetal rat (14), Sarcoma 37 cells (4), HeLa cells (5), Ehrlich and Yoshida ascites tumor cells (20), m ammary carcinoma cells of the rat (16), and cells of a chicken fibrosarcoma (3). Neither the orig...

Objective: To evaluate the antitumor activity of the ethanol extract of Indigofera aspalathoides (EIA) in mice. Material and Methods: The antitumor activity of EIA was evaluated against the Ehrlich ascites carcinoma (EAC) tumor model. The activity was assessed using survival time, peritoneal cell count, hematological studies, solid tumor mass and in vitro cytotoxicity. Results: Oral administrat...

OBJECTIVE Benzophenone semicarbazone (BSC) was synthesized and characterized to identify compounds with anticancer activities. METHODS Anticancer activities were studied against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement, survival time of tumor bearing mice, tumor cell growth inhibition, and so on. Some hematological pa...

It was recently reported by Iglewski and Rittenberg in THESE PROCEEDINGS (71, 2707-2710, 1974) that low doses of purified diphtheria toxin inhibit protein synthesis in mouse Ehrlich-Lettre ascites carcinoma cells cultured in vitro. These observations could not be confirmed by us nor could the authors' further claim that toxin can cause regression of well-established ascites tumors in preimmuniz...

Ascofuranone (AF) showed an antitumor protective effect on L-1210 leukemia when AF was administered once 7 days before tumor challenge. However, effect was not elicited when host mice were treated with AF simultaneously with tumor challenge. AF pretreatment on day 7, 5 and 3 before tumor challenge protected the host from the ascites form of S-180. AF also retarded tumor growth when administered...