Within a 3D tissue, cells need to integrate signals from growth factors, such as BMPs, and the extracellular matrix (ECM) to coordinate growth and differentiation. Here, we use the Drosophila embryo as a model to investigate how BMP responses are influenced by a cell's local ECM environment. We show that integrins, which are ECM receptors, are absolutely required for peak BMP signaling. This st...

The benefits from ICT investments materialize through sustained usage rather than initial acceptance. Hence, the amount of research on continued IT usage (IS continuance) employing the ExpectationConfirmation Model (ECM) has been increasing steadily in recent years. In this body of literature, empirical results regarding the correlations between the key constructs of ECM have not been entirely ...

Volvox is one of the simplest multicellular organisms with only two cell types, yet it has a surprisingly complex extracellular matrix (ECM) containing many region-specific morphological components, making Volvox suitable as a model system for ECM investigations. ECM deposition begins shortly after inversion, which is the process by which the embryo turns itself right-side-out at the end of emb...

results migration of cells started on the fifth day. as a result of this migration, most cells were located on the surface of the scaffold and formed epiderm-like structure and some penetrated into the scaffold. by day 25, cells which had penetrated into the scaffold had various destinies such as becoming elongated spindle-shaped cells and creating blood vessel-like structures. conclusions adm ...

This paper presents a system of recommendations for an enterprise content manager (ECM) based on ontological models. In many occasions the results of a search are not accurate enough, so the user of the ECM system must check them and discard those not related to the search. In order to make recommendations, a proposal where it is necessary to review the instances of the ontological model is pre...

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