It was confirmed that CD147 (Emmprin) was expressed on the cell surface of carcinoma cells. For the purpose of studying the efficacy of a CD147-targeting agent on CD147-expressing carcinoma cells, we investigated the effect of a conjugate of glutathione-doxorubicin (GSH-DXR) encapsulated in an anti-CD147 antibody-labeled liposome (aCD147ab-liposome) in terms of specific accumulation and cytotox...

Streptomyces griseolosporeus MF730-N6, a terpenoid antibiotic-terpentecin (Tp) producer, has both the nonmevalonate and mevalonate pathways for the formation of IPP. The Tp biosynthetic gene (ter) and the mevalonate pathway gene cluster (mev) including an HMG-CoA reductase gene (hmgr) had previously been cloned from strain MF730-N6. In this study, two distinct dxs genes (dxs 1 and dxs 2) and a ...

Introduction Malaria is one of the world’s most serious parasitic diseases. There are estimated 300-500 million cases and more than a million deaths from malaria each year. Human malaria is caused by infection with intracellular parasites of the genus Plasmodium that are transmitted by Anopheles mosquitoes. Plasmodium falciparum is the most lethal among the four species of Plasmodium that infec...

This paper deals with spectral type differential equations of the self-adjoint differential operator, 2r order: L(2r)[Y ](x)= 1 (x) d dxr ( (x) r (x) dY (x) dxr ) = rnY (x). If (x) is the weight function and (x) is a second degree polynomial function, then the corresponding classical orthogonal polynomials, {Qn(x)}∞n=0, are shown to satisfy this differential equation when rn is given by rn = r−...

In this study, we reported for the first time that a new compound named 3113, which is the dipeptidomimetic of paminobenzoic acid showed multi-drug resistance (MDR) reversal activity. In MDR cancer cells, no matter acquired or inherent, combination with 3113 enhanced doxorubicin (DXR) cytotoxicity by 8 to 10 folds, which was slightly higher than the effect of verapamil (VPL). 3113 was indicated...

The human malaria parasite Plasmodium falciparum is responsible for the deaths of more than a million people each year. Fosmidomycin has been proven to be efficient in the treatment of P. falciparum malaria by inhibiting 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an enzyme of the non-mevalonate pathway, which is absent in humans. However, the structural details of DXR inhibition by ...

Isoprenoid biosynthesis through the methylerythritol phosphate (MEP) pathway generates commercially important products and is a target for antimicrobial drug development. MEP pathway regulation is poorly understood in microorganisms. Here we employ a forward genetics approach to understand MEP pathway regulation in the malaria parasite, Plasmodium falciparum. The antimalarial fosmidomycin inhib...

After invasive ductal carcinoma, lobular carcinoma (ILC) is the most frequent breast cancer and accounts for nearly 15% of all cancers (BC). Doxorubicin (DXR) a very effective chemotherapeutic drug utilized to treat BC but induces resistance severe side effects. Recently, liposomes have gained popularity as tumor microenvironment (TME) modulatory anticancer agents various malignancies, includin...