PURPOSE The volume effect of ionization chambers gives rise to a spatial averaging effect that can be expressed mathematically as the convolution of the true dose profile with the detector's response function. The latter has been shown to be best described by Gaussian distribution. Based on this knowledge, the volume effect correction factor kV is derived. METHODS To derive kV, a sixth degree...

AbstractIntroduction Silicone gel breast implants are used for breast reconstruction post mastectomy. In the event of cancer recurrence, the radiation oncologists are forced to irradiate through the prosthesis device. Due to prosthesis higher atomic number dose perturbations occur during treatment. This study determined the influence of silicone gel thickness on the photon beam distribution. Ma...

background: to suggest south india ct diagnostic reference levels (drls) by collecting radiation doses for the most commonly performed ct examinations. materials and methods: a pilot study investigated the most frequent ct examinations. 110 ct sites were asked to complete a survey booklet to allow the recording of ct parameters for each of 3 ct examinations during a 1 year time period. dose dat...

Objective This study aimed to determine if 0.15 mg/kg intravenous (IV) subdissociative ketamine is noninferior 0.3 in emergency department (ED) patients with acute pain. Methods randomized, prospective, double-blinded, noninferiority trial included patients’ age 18 59 years presenting the ED moderate severe Subjects were randomized IV ketamine, ("low" dose) or 0.30 ("high" dose), over 15 minute...

CIGB-552 is a synthetic peptide that interacts with COMMD1 and upregulates its protein levels. The objectives of this phase I study were safety, pharmacokinetic profile, evaluation the lymphocytes CD4+ CD8+ preliminary activity in patients advanced tumors. A 3 + dose-escalation design seven dose levels was implemented. Patients included until grade related adverse event occurred maximum tolerat...

background: understanding of the incident electron energy and angular distributions from clinical electron accelerators (linacs) is important for dosimetry and treatment planning. the most important goals of this study were to evaluate the energy fluence and angular distributions of electron beams from a neptun 10pc linac using the monte carlo (mc) code. materials and methods: the linac electro...

Indiplon (NBI 34060; N-methyl-N-[3-[3-(2-thienylcarbonyl)-pyrazolo[1,5-alpha]pyrimidin-7-yl]phenyl]acetamide), a novel pyrazolopyrimidine and high-affinity allosteric potentiator of GABA(A) receptor function, was profiled for its effects in rodents after oral administration. In mice, indiplon inhibited locomotor activity (ED(50) = 2.7 mg/kg p.o.) at doses lower than the nonbenzodiazepine hypnot...

AIMS To study the effect and time profile of different doses of testosterone enanthate on the blood lipid profile and gonadotropins. EXPERIMENTAL DESIGN Twenty-five healthy male volunteers aged 27-43 years were given 500 mg, 250 mg, and 125 mg of testosterone enanthate as single intramuscular doses of Testoviron(®) Depot. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), blood lip...

introduction: coronary angiography and angioplasty procedures lead to significant radiation exposure of patients. in the current study, the average radiation dose to patients during angiography in the angiography department of shahid-madani hospital was determined. materials and methods: an image intensifier based angiography unit (philips bh 3000) was used for angiography procedures. the accur...

introduction: in 2000, the unscear reported that ct constitutes 5% of all the medical x-ray  examinations and it contributes 34% of the resultant collective dose worldwide. children are more  sensitive to the ionizing radiations than adults. so, routine quality control tests are expected to be  carried out periodically on the ct scanners. the aim of this research was to estimate the effective  ...