نتایج جستجو برای: dopamine d3 receptor
تعداد نتایج: 632920 فیلتر نتایج به سال:
Dysregulation of dopamine transmission is thought to contribute to schizophrenic psychosis and drug dependence. Dopamine release is regulated by D2 dopamine autoreceptors, and D2 receptor ligands are used to treat psychosis and addiction. To elucidate the long-term effects of D2 autoreceptor activity on dopamine signaling, dopamine overflow evoked by single or paired-pulse stimulation was compa...
Pharmacological studies suggest that dopamine release from lateral olivocochlear efferent neurons suppresses spontaneous and sound-evoked activity in cochlear nerve fibers and helps control noise-induced excitotoxicity; however, the literature on cochlear expression and localization of dopamine receptors is contradictory. To better characterize cochlear dopaminergic signaling, we studied recept...
CONTEXT Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent psychiatric disorder of childhood. There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed. OBJECTIVE To test the hypotheses that striatal dopamine activity is depressed in ADHD and that this contributes to symptoms of inattention. ...
Background Opiate addiction is associated with complex cognitive impairment, which contributes to the development of compulsive drug use and relapses. Dopamine and N-methyl-D-aspartate receptors play critical roles in opiate-induced cognitive deficits. However, the roles of D1 and D3 receptors in the N-methyl-D-aspartate/glycineB receptor-regulated cognitive behaviors induced by morphine remain...
Rats experimentally infected with the neurotropic RNA virus, Borna disease virus, have a hyperactive movement disorder. Because locomotor activity is modulated by the nucleus accumbens (N. Acc.) dopamine (DA) system, high-affinity DA uptake, DA D1, D2, and D3 receptor binding sites were examined in N. Acc. subregions of normal and infected rats by quantitative receptor autoradiography. The N. A...
A number of studies have recently suggested that the D3 receptor [ 11 is located presynaptically and functions as an autoreceptor [2-41. These studies have demonstrated that 7-hydroxy-di-npropyl-2-aminotetralin [ ( + )-7-OH-DPAT], a ligand with significant D3 receptor affinity, decreases dopamine release in limbic and striatal regions. However, the selectivity of (+)-7-OHDPAT for the D3 recepto...
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