The present model discusses the drug distribution in the layers of human dermal parts. We have considered tissue absorption rate of drug is decreasing function of drug concentration, also considered linear shape functions for approximating element wise approximate solution by Finite Element Method (FEM).In this method each region is referred to as an element and the process of subdividing a dom...

Isobutylene has a low order of acute toxicity. As isobutylene is a gas at normal temperature and pressure, ingestion or dermal absorption of this material is unlikely. The 2-hour LC50 of isobutylene in mice was 180,000 ppm (415 mg/L) and the 4-hour LC50 in rats was 270,000 ppm (620 mg/L). Inhalation of isobutylene can produce central nervous system depression, anesthesia and/or asphyxiation. Ho...

Author Steven Zeisel believes DEA could induce fetal neural abnormalities in humans, too. “It’s hard to estimate human exposure, but we believe the mice had exposures about ten times higher,” he says, assuming that people bathe and shampoo daily with DEA-containing products, and use DEAcontaining sunscreen. “There’s no reason to believe we wouldn’t see similar effects in humans.” The authors no...

Methylsalicylate-containing rubefacients have been reported to cause salicylate poisoning after ingestion, topical application to abnormal skin, and inappropriate topical application to normal skin. Many over-the-counter products contain methylsalicylate. Topical salicylates rarely produce systemic toxicity when used appropriately; however, methylsaliclyate can be absorbed through intact skin. ...

Polymeric hydrogels are used as wound dressing material since these materials show advantages such as pain relief, exudates absorption, barrier to microorganisms, permeability, and others. This article shows the results obtained in a study aiming to know the biological performance of different polymeric materials to be used in contact with skin: PVP hydrogels and acrylate adhesive. The biocompa...

The systemic uptake of chloroform from dilute aqueous solutions into live hairless rats under conditions simulating dermal environmental exposure was studied. Whole blood was sampled during a 30-min immersion of an animal within water containing a known concentration of chloroform and then for 5.5 h following its removal from the bath. The amount of chloroform systemically absorbed was determin...

With increasing use of dermal fillers, more and more adverse effects are reported. The most devastating one is intravascular injection. We propose a novel needle prototype that allows physicians to prevent intravascular injection.

Talius is a new fungicide containing the active substance proquinazid. against cereal powdery mildew (Blumeria graminis) in cereals and grass seed. The risk assessment was finalized at meeting Mai 29, 2012, by VKM’s Scientific Panel on plant protection products (VKM). VKM particular asked Norwegian Food Safety Authority to look following: 
 human health for operators related properties of ...