Nicotine exerts a number of physiological effects. Nicotine is absorbed through the lungs with smoking and is rapidly metabolized in humans. Although it is mainly metabolized in the liver, the effects of liver injuries on nicotine metabolism are not clear. The purpose of this study was to clarify the effects of liver injuries on nicotine metabolism. Rats were treated with D-galactosamine (GalN)...

12-Hydroxyeicosatetraenoic acid (12-HETE) is formed from arachidonic acid either by 12-lipoxygenase or by a cytochrome P450 monooxygenase. 12-Lipoxygenase is generally localized in the soluble cytosolic fraction, and the cytochrome P450 monooxygenase is a microsomal enzyme. In this study, 12-HETE biosynthesis and the regulation of 12-HETE biosynthesis by epidermal growth factor (EGF) in A431 ce...

CYP6B1 represents the principal cytochrome P450 monooxygenase responsible for metabolizing furanocoumarins in Papilio polyxenes, an insect that specializes on host plants containing these toxins. Investigations of the amino acids responsible for the efficient metabolism of these plant toxins has identified Ile115 as one that modulates the rate of furanocoumarin metabolism even though it is pred...

Resistance to phosphine fumigation in stored insects continues be challenging managing these pests worldwide. The role of detoxification enzymes metabolizing is yet explored fully. dose-response mortality against was assessed this study from six field populations Tribolium castaneum (Herbst) collected across India during 2021–23 at the Division Entomology, ICAR-Indian Agricultural Research Inst...

To explore the contribution of agricultural practices on enzymatic activity in Anopheles gambiae populations, collections gambiaelarve were done cotton vegetable farming (famers use for both,insecticides pest control) and subsistence (no insecticide) from district Banikoara, located Benin. Enzymatic activities such as total protein, monooxygenase P450, Glutathione-S-Transferase esterasewere inv...