نتایج جستجو برای: cutaneous wound

تعداد نتایج: 122549  

Objective(s) Wound licking has been shown to advance wound healing among humans and many other animals. The present study evaluates the licking effects on healing of skin wound in rats. Materials and Methods Twenty four rats were assigned to 4 different groups randomly and two 3 cm longitudinal full thickness incisions were made on each dorsal and ventral side of rats. The ventral incisions ...

Journal: :International journal of molecular medicine 2013
Xiaoyu Liu Zhe Wang Rui Wang Feng Zhao Ping Shi Yide Jiang Xining Pang

Although transplantation of human mesenchymal stem cells (MSCs) derived from amnion (hAMSCs), bone marrow (hBMSCs) and adipose tissues (hADSCs) has been shown to aid in the repair of cutaneous wounds in mouse models, little information is available regarding the relative efficacy of MSCs from different sources. In this study, we compared their therapeutic potentials by transplanting equal numbe...

Journal: :The International journal of developmental biology 1989
R Murakami I Yamaoka T Sakakura

Distribution of the extracellular matrix glycoprotein tenascin during wound healing in mouse skin was studied immunohistochemically. Within 24 hours after wounding, and preceding the formation of granulation tissue, tenascin appeared in the basement membranes beneath epidermis and hair follicles adjacent to the wound edges and in the wounded edges of cutaneous muscle layer. Granulation tissue b...

2015
Le Thi Lien Nguyen Thi Tho Do Minh Ha Pham Luong Hang Phan Tuan Nghia Nguyen Dinh Thang

BACKGROUND Wound healing has being extensively investigated over the world. Healing impairment is caused by many reasons including increasing of free-radicals-mediated damage, delaying in granulation tissue formation, reducing in angiogenesis and decreasing in collagen reorganization. These facts consequently lead to chronic wound healing. Piper betle Linn (Betle) leaves have been folklore used...

2011
Kenichiro Kawai Barrett J. Larson Hisako Ishise Antoine Lyonel Carre Soh Nishimoto Michael Longaker H. Peter Lorenz

INTRODUCTION Nanoparticles (NPs) are small entities that consist of a hydroxyapatite core, which can bind ions, proteins, and other organic molecules from the surrounding environment. These small conglomerations can influence environmental calcium levels and have the potential to modulate calcium homeostasis in vivo. Nanoparticles have been associated with various calcium-mediated disease proce...

2016
Hong Huang Jiejie Liu Haojie Hao Chuan Tong Dongdong Ti Huiling Liu Haijing Song Chaoguang Jiang Xiaobing Fu Weidong Han

OBJECTIVE To evaluate the therapeutic effects of G-CSF administration after intraosseous (IO) resuscitation in hemorrhagic shock (HS) combined with cutaneous injury rats. METHODS The rats were randomly divided into four groups: (1) HS with resuscitation (blank), (2) HS with resuscitation + G-CSF (G-CSF, 200 μg/kg body weight, subcutaneous injection), (3) HS with resuscitation + normal saline ...

Journal: :Journal of cell science 2006
Stephen C Gilliver Jason J Ashworth Stuart J Mills Matthew J Hardman Gillian S Ashcroft

Impaired wound healing states in the elderly lead to substantial morbidity and mortality, and a cost to the health services of over 9 billion dollars per annum. In addition to intrinsic ageing processes that per se cause delayed healing, studies have suggested marked differences in wound repair between the sexes. We have previously reported that, castration of male mice results in a striking ac...

Journal: :Endocrinology 2001
J T Fassett M Nilsen-Hamilton

During cutaneous wound healing, a marked increase in the local expression of growth factors results in increased migration and proliferation of the cells responsible for tissue repair. The mitogen-regulated protein (MRP)/proliferin proteins are growth factors and angiogenesis factors. Here it is demonstrated that Mrp3 is induced in wound edge keratinocytes during cutaneous wound healing and als...

2016
Flavia Bruna David Contador Paulette Conget Benjamín Erranz Claudia L. Sossa Martha L. Arango-Rodríguez

Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant. No systematic information is currently available regarding whether donor age modifies MSC regenerative potential on cutaneous wound healing. Here, we evaluate whether donor age influences this potential. Two different doses of bone marrow MSCs (BM-MSCs) from young, adu...

2014
Nadine Jetten Nadia Roumans Marion J. Gijbels Andrea Romano Mark J. Post Menno P. J. de Winther Rene R. W. J. van der Hulst Sofia Xanthoulea

Macrophages play a crucial role in all stages of cutaneous wound healing responses and dysregulation of macrophage function can result in derailed wound repair. The phenotype of macrophages is influenced by the wound microenvironment and evolves during healing from a more pro-inflammatory (M1) profile in early stages, to a less inflammatory pro-healing (M2) phenotype in later stages of repair. ...

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