Ileal pouch-anal anastomosis (IPAA) is an excellent surgical option for patients with chronic ulcerative colitis (CUC) requiring colectomy; however, persistent episodes of ileal pouch inflammation, or pouchitis, may result in debilitating postoperative complications. Because considerable evidence implicates substance P (SP) as an inflammatory mediator of CUC, we investigated whether SP particip...

The structure and local structural distortions, through the polarization manipulation, of crystalline films of ferroelectric vinylidene fluoride (70%) with trifluoroethylene (30%) [P(VDF-TrFE)] copolymer on graphite were studied by scanning tunneling microscopy (STM). A quasispiral twist in CuC bonds with rotations about the polymer chain axis was observed by high-resolution STM, indicating a s...

We propose to model multivariate volatility processes based on the newly defined conditionally uncorrelated components (CUCs). This model represents a parsimonious representation for matrix-valued processes. It is flexible in the sense that we may fit each CUC with any appropriate univariate volatility model. Computationally it splits one high-dimensional optimization problem into several lower...

The follow up of patients on active surveillance requires to repeat prostate biopsies. Predictive models that identify patients at low risk of progression or reclassification are essential to reduce the number of unnecessary biopsies. The aim of this study is to validate the Prostate Active Surveillance Study risk calculator (PASS-RC) in the multicentric Spanish Urological Association Registry ...