Abstract Background Malignant brain tumors are the cause of a disproportionate level morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in molecular characterization these tumors, targeting cells yet to produce significant treatment. An alternative strategy is target glioblastoma microenvironment, such as...

Background Imbalanced nutritional supply and demand in the tumor microenvironment often leads to hypoxia. The subtle interaction between hypoxia immune cell behavior plays an important role occurrence development. However, functional relationship remains unclear. Therefore, we aimed investigate effect of on intestinal microenvironment. Method We extracted names hypoxia-related genes from Gene S...

Polymorphic light eruption (PLE) is a chronic intermittent skin disease that develops episodes after sun exposure, most often in spring or early summer. Although the pathogenesis not fully understood, evidence indicates microbiome may play crucial role. Preclinical data have shown can regulate UV-induced cytokine expression and modulate subsequent immune response. We therefore hypothesized of P...

Tumor-associated macrophages (TAMs) of the immune microenvironment play an important role in Diffuse Large B-cell Lymphoma (DLBCL) pathogenesis. This research aimed to characterize expression macrophage colony-stimulating factor 1 receptor (CSF1R) at gene and protein level correlation with survival. First, immunohistochemical CSF1R was analyzed a series 198 cases from Tokai University Hospital ...

Abstract Exposure to social adversity can influence the onset and progression of disease. One possible mechanism through which may impact health outcomes is by altering immune homeostasis. Recently, evidence has connected changes in gene regulation response both humans nonhuman primates. We investigated how (quantified as low status) affected Th2 free-ranging male rhesus macaques (n=128). stimu...