نتایج جستجو برای: corneal neovascularization

تعداد نتایج: 38838  

Journal: :The EMBO journal 1999
T Asahara T Takahashi H Masuda C Kalka D Chen H Iwaguro Y Inai M Silver J M Isner

Vascular endothelial growth factor (VEGF) has been shown to promote neovascularization in animal models and, more recently, in human subjects. This feature has been assumed to result exclusively from its direct effects on fully differentiated endothelial cells, i.e. angiogenesis. Given its regulatory role in both angiogenesis and vasculogenesis during fetal development, we investigated the hypo...

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2012
Doreswamy Kenchegowda Stephen A. K. Harvey Sudha Swamynathan Kira L. Lathrop Shivalingappa K. Swamynathan

BACKGROUND Klf5 plays an important role in maturation and maintenance of the mouse ocular surface. Here, we quantify WT and Klf5-conditional null (Klf5CN) corneal gene expression, identify Klf5-target genes and compare them with the previously identified Klf4-target genes to understand the molecular basis for non-redundant functions of Klf4 and Klf5 in the cornea. METHODOLOGY/PRINCIPAL FINDIN...

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Journal: :The British journal of ophthalmology 1953
C COOK M LANGHAM

THE importance of the role played by changes in the thickness of the cornea in the induction of corneal vascularization has recently become increasingly recognized (Cogan, 1948; Ashton, Cook, and Langham, 1951; Langham, 1952, 1953; Ashton and Cook, 1953). However the relationship between the swelling and increase in opacity of the cornea to the rate and progress of vascularization of the cornea...

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Journal: :Journal of pharmacological sciences 2007
Hirotsugu Ogura Takako Nakanishi-Ueda Toshihiko Ueda Shinichi Iwai Seiichi Uchida Yuta Saito Yoko Taguchi Hajime Yasuhara Donald Armstrong Katsuji Oguchi Ryohei Koide

The aim of this study was to investigate the effect of A-3922, a dihydrobenzofuran derivative, on linoleic acid hydroperoxide (LHP)-induced corneal neovascularization (NV) in a rabbit model. Male New Zealand rabbits received intraperitoneal (i.p.) injections of 10 or 30 mg/kg per day A-3922 or its vehicle as control for 3 days. One day after i.p. injections, LHP was injected with a 30-gauge nee...

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Journal: :Korean Journal of Ophthalmology 2010

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Journal: :Mammalian Genome 2013

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Journal: :Proceedings for Annual Meeting of The Japanese Pharmacological Society 2018

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Journal: :Journal of Medicinal Food 2016

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Journal: :Türk Oftalmoloji Dergisi 2015

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2017
Yan Zhang Siwei Cai Yurong Jia Chen Qi Jing Sun Hong Zhang Fei Wang Yunshan Cao Xiaorong Li

Ocular neovascularization is a pathological sequel of multiple eye diseases. Based on the anatomical site into which the abnormal neovessels grow, ocular neovascularization can be categorized into corneal neovascularization, choroidal neovascularization, and retinal neovascularization. Each category is intractable, and may lead to blindness if not appropriately treated. However, the current the...

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