purpose: congenital corneal leukoma is rare with an incidence of 6/100000 and is one of the most important causes of amblyopia. here we report an unusual case of bilateral congenital elevated corneal leukoma. methods: we encountered a 13-day-old full term male newborn. ocular examination of both eyes revealed central elevated corneal leukomas with a narrow normal lucid interval to limbus. corne...

PURPOSE To investigate the involvement of the cornea during endotoxin-induced uveitis (EIU) in the rat and the effect of Ngamma-nitro-L-arginine methyl ester (L-NAME) as nitric oxide synthase (NOS) inhibitor, administered by iontophoresis. METHODS EIU was induced in Lewis rats that were killed at 8 and 16 hours after lipopolysaccharide (LPS) injection. The severity of uveitis was evaluated cl...

Recent work has shown remarkable plasticity between neural and hematopoeitic, as well as between hematopoeitic and muscle stem cells, depending on environmental stimuli (Fuchs, E. and Segre, J. A. (2000) Cell 100, 143-155). Stem cells give rise to a proliferative transient amplifying population (TA), which is generally considered to be irreversibly committed. Corneal epithelium provides a parti...

Report keratoconus in two patients with a long history of wrestling without any risk factor for corneal ectasia and reviewing the possible pathogenesis. To confirm suspicion of keratoconus, corneal topography was performed using scanning slit topography system and Orbscan. In two wrestlers with the complaint of visual loss in their eyes and IOP raising, corneal topography was performed and de...

PURPOSE To determine whether topical ocular delivery of <100 nm nanoparticles can be enhanced by coating their exterior with peptide or protein ligands for cell surface receptors. METHODS A novel ex vivo bovine eye model was validated for its integrity up to 60 min. Using this model, the uptake of 20 nm polystyrene nanoparticles (administered as a single 50 mul drop) before and after surface ...

At the time of writing, the most advanced technique of LASIK uses a femtosecond laser for the creation of the flap. This instrument has reduced the complications associated with the creation of the corneal flap to a minumum, with a reduction in the cut depth and a consequent increase in the thickness of the residual stromal bed. The femtosecond laser can therefore be considered to be a major ev...

BACKGROUND To study the effect of topical administration of a fusion protein (PF-MC) made up of N-terminal portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-2) and SLPI (protein with anti-inflammatory, anti-bacterial and anti-viral ability), in an animal model of corneal inflammation and angiogenesis. METHODS An alkali injury was produced with a filter pape...

Deep Anterior lamellar Keratoplasty (DALK) has become the corneal transplantation technique of choice for corneal diseases that spare the corneal endothelium. The major indications include keratoconus, stromal corneal dystrophies, corneal scars that spare the Descemet membrane (DM) and recalcitrant infectious keratitis. Unlike the old technique of penetrating/full thickness corneal transplantat...

PURPOSE To investigate the clinical outcomes of cultivated corneal limbal epithelial transplantation (CLET) using human amniotic membrane for corneal limbal stem-cell deficiency. METHODS Prospective, noncomparative case series. Eighteen patients (19 eyes) with severe ocular surface diseases were chosen to undergo CLET using human amniotic membrane. Twelve eyes received auto-CLET, and seven ey...