introduction: recurrent corneal erosion occurs when the wounded corneal epithelium failed to adhere to the underlying stroma. therefore, this work aimed to assess the effect of treatment of corneal injury using q- switched nd:yag laser.  method: twenty one new zealand male rabbits weighing 2-2.5 kg and 3 months old were classified into three main groups. the control group: did not received any ...

Corneal epithelial stem cells are thought to be localized in the basal cell layer of the limbus. We developed a monoclonal antibody designated 4G10.3 that immunolocalized to limbal basal cells in rat corneas. Western blot analysis demonstrated that 4G10.3 reacted with a single band of 50,000 molecular weight in rat and rabbit corneal epithelium and 48,000-49,000 in human epithelium. Following e...

PURPOSE This study was undertaken to investigate the role of the antiangiogenic receptor CD36 during inflammatory corneal neovascularization (CNV). METHODS In a murine model of inflammatory CNV, CD36 expression was evaluated by RT-PCR and immunofluorescence. Mice subjected to CNV were treated topically (thrice daily) with CD36 functionally neutralizing antibodies against the oxidized low-dens...

Previous investigations of corneal neovascularization after irradiation yielded discordant results. Most studies indicated that new blood vessel formation in the cornea is inhibited by irradiation. However, others reported that angiogenesis after corneal cauterization is similar in both irradiated and nonirradiated animals. To assess the effect of total-body irradiation on neovascularization fu...

Ascorbic acid, a water soluble vitamin, helps in collagen assembly, synthesis of neurotransmitters, has immune functions and also acts as a major antioxidant in the body. Refractory corneal ulcer is a challenging situation faced by every ophthalmologist in developing countries. Available treatment options for refractory corneal ulcer are bandage contact lens, grid keratotomy, therapeutic penetr...

A 47-year-old man presented at the Ophthalmology Department of Saku City Asama General Hospital complaining of hyperemia and pain after industrial sodium hydroxide (approx. 40% concentration) had entered his left eye. With an epithelial defect of the bulbar and palpebral conjunctiva, ischemia of the inferior third of the limbal conjunctiva, a total corneal epithelial defect and mild corneal str...

For study of corneal adhesion after chemical injury, sulfuric acid was used to burn the central and peripheral corneal epithelium in rhesus monkeys. The adhesion properties of the regenerating epithelium were sequentially followed by clinical assessment and by serial corneal biopsy specimens examined by transmission electron microscopy. The peripheral burns healed uneventfully, but the central ...

A 40-years-old male patient with a corneal scar secondary to perforating eye injury had undergone ipsilateral rotational autokeratoplasty in our clinics. The corneal scar involved the pupillary area. The patient had a preoperative visual acuity of counting fingers. The patient's cornea was trephined with a 0.5 mm temporal decentration. The 8.0 mm autograft was rotated approximately 180° to relo...

PURPOSE Although cryotherapy has long been used to eradicate corneal lesions, there have been no reports of adverse effects of cryotherapy on human corneas. We performed this study to evaluate and characterize ultrastructural damage to the human cornea following the transcorneal freezing-and-thawing procedure. METHODS Seven human donor corneas were randomly divided into three groups. 1, 2, an...

PURPOSE To establish whether fucoidin, by blocking the adhesion of leukocytes on the limbal vascular endothelium, prevents extravasation of the cells from the blood stream into the limbal stroma and the wounded area after corneal injury. Successful leukocyte blocking enabled investigation of the influence of leukocytes on corneal cellular proliferation after corneal wounding. METHODS Thirty-t...