A diffusion method for determining the sensitivity of pathogenic fungi to therapeutic agents is described using tablets containing the following antibiotics: amphotericin B, clotrimazole, econazole, fluorocytosine, and miconazole. The composition of the media used, standardisation of inocula, incubation time, and temperature are detailed.

OBJECTIVES In otomycosis with tympanic membrane perforation, many physicians prefer to insert an ear wick medicated with antimycotic cream. This needs multiple visits to the clinic and keeps the ear blocked for several days. Direct instillation of alcohol based antimycotic solution causes severe burning if it reaches the middle ear. In this work we compare patient's self medication with clotrim...

Vaginal dosage forms are seen as a viable option for empowering women to protect themselves from the risk of HIV transmission. Because of limited research in the field, there is a lack of suitable dissolution methods established for determination of drug release from vaginal formulations inside the vaginal tract. The main aim of this study was to develop a simple, reliable and reproducible in v...

PURPOSE To study the epidemiology of oral candidiasis and the effect of treatment of thrush in human immunodeficiency virus (HIV)-infected patients. PATIENTS AND METHODS We conducted a prospective observational study of 92 patients over 1 year, including a nonblinded, randomized treatment trial of thrush with clotrimazole troches or oral fluconazole. Oral sites were cultured monthly and when ...

The “standard” heat-clot method of London and Marymont is shown here to be applicable to the determination of creatinine. With this method creatinine can be assayed in very small quantities of serum, and only a conventional laboratory reagent, alkaline picrate, is required. A new fast technic has been developed in which extraction of the clot is carried out for only 10 mm. at a high temperature...

Mits. ? ,aged 84, was admitted into hospital on the 7th October 1890 with a previous history of having had five children and one abortion. The last child was born two years ago. She stated that she had been regular up to August last when she missed a period. About September 9th when her period was due she felt very bad suddenly, and this was followed by great pain shooting up from the left side...

Dong, Hui, Anders Smith, Marjan Hovaida, and Jimmy Y. Chow. Role of Ca -activated K channels in duodenal mucosal ion transport and bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 291: G1120–G1128, 2006. First published June 8, 2006; doi:10.1152/ajpgi.00566.2005.—Stimulation of muscarinic receptors in the duodenal mucosa raises cytosolic free Ca concentration ([Ca ]cyt), thereby r...