In the no-boundary universe the universe is created from an instanton. However, there does not exist any instanton for the “realistic” FRW universe with a scalar field. The “instanton” leading to its quantum creation may be modified and reinterpreted as a constrained gravitational instanton. PACS number(s): 98.80.Hw, 98.80.Bp, 04.60.Kz, 04.70.Dy

There is fundamental knowledge that during the resting state cerebral activity recorded by electroencephalography (EEG) is strongly modulated by the eyes-closed condition compared to the eyes-open condition, especially in the occipital lobe. However, little research has demonstrated the influence of the eyes-closed condition on the motor cortex, particularly during a self-paced movement. This p...

Analysis of fringe patterns with partial--field and/or closed fringes is still a challenging problem that requires the development of robust methods. This paper presents a method for fringe pattern analysis with those characteristics. The method is initially introduced as a phase refinement process for computed coarse phases, as those obtained from partial--field patterns with a full-field meth...

We introduced disulfide bonds to lock the integrin alphaLbeta2 I domain in predicted open, ligand binding or closed, nonbinding conformations. Transfectants expressing alphaLbeta2 heterodimers containing locked-open but not locked-closed or wild-type I domains constitutively adhered to intercellular adhesion molecule-1 (ICAM-1) substrates. Locking the I domain closed abolished constitutive and ...

the identity of dead is an essential part of post-mortem examination. the identification of unknown human remnants begins with the creation of an anthropological profile, which includes sex, biological age, stature and individualizing features. the estimation of age at death is based on the bodily biological changes that occur throughout life. closure of spheno occipital synchondrosis is one of...

introduction: intramedullary nailing (imn) of high tibia fracture has some mechanical and biological advantages over the other form of fixation. however, valgus, apex anterior malalignment and anterior displacement of proximal fragment commonly occur after isolated imn fixation of proximal high tibia fracture. the purpose of this study is to determine the effectiveness of using 3.5-mm locking c...

Reduction and avoidance of increases in intracranial pressure (ICP) after severe traumatic brain injury (TBI) continue to be the mainstays of treatment. Traumatic axonal injury is a major contributor to morbidity after TBI, but it remains unclear whether elevations in ICP influence axonal injury. Here we tested the hypothesis that reduction in elevations in ICP after experimental TBI would resu...

The treatment of comminuted fractures of the mandible is challenging due both to the severity of the injuries generally associated with this type of fracture, and the lack of consensus as to the most appropriate treatment method.There are two distinct approaches for treating comminuted fractures of the mandible: closed reduction with maxillomandibular fixation (MMF) - the oldest and classical t...

An approach for the control and understanding of supported molecular catalysts is demonstrated with the design and synthesis of open and closed variants of a grafted Lewis acid active site, consisting of Al(III)-calix[4]arene complexes on the surface of silica. The calixarene acts as a molecular template that enforces open and closed resting-state coordination geometries surrounding the metal a...