BACKGROUND Allergy to cat dander is a common form of allergic disease. Allergen immunotherapy has been demonstrated to be effective in decreasing allergic symptoms. OBJECTIVES To examine outcomes in allergic asthmatic patients on cat immunotherapy (CIT) compared to allergic asthmatics on traditional immunotherapy (IT) without cat sensitivity. METHODS A retrospective review identified allerg...

Hyperechogenic signal of substantia nigra (SN) in transcranial sonography (TCS) and reduced striatal uptake in FP-CIT SPECT are commonfindings in idiopathic Parkinson’s disease (PD). But so far it is unknownwhether the extent of SN hyperechogenicity represents a correlate for the degeneration of presynaptic dopaminergic neurons in PD. We performed TCS and I-labelled N-(3-fluoropropyl)-2ß-carbom...

Attentional, intentional, and motivational factors are known to influence the physiological responses in a Concealed Information Test (CIT). Although concealing information is essentially a social action closely related to motivation, CIT studies typically rely on testing participants in an environment lacking of social stimuli: subjects interact with a computer while sitting alone in an experi...

Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allosterically activated by citrate (CIT) and ADP. In this work, we report the cry...

The possibility to enhance the detection efficiency of the Concealed Information Test (CIT) by increasing executive load was investigated, using an interference design. After learning and executing a mock crime scenario, subjects underwent three deception detection tests: an RT-based CIT, an RT-based CIT plus a concurrent memory task (CITMem), and an RT-based CIT plus a concurrent set-shifting ...

Cytokinesis culminates in the final separation, or abscission, of the two daughter cells at the end of cell division. Abscission relies on an organelle, the midbody, which forms at the intercellular bridge and is composed of various proteins arranged in a precise stereotypic pattern. The molecular mechanisms controlling midbody organization and function, however, are obscure. Here we show that ...

Assessing treatment effects in observational studies is a multifaceted problem that not only involves heterogeneous mechanisms of how the treatment or cause is exposed to subjects, known as propensity, but also differential causal effects across sub-populations. We introduce a concept termed the facilitating score to account for both the confounding and interacting impacts of covariates on the ...

The serology of patients with Rheumatoid arthritis (RA) is characterized by persistently raised levels of autoantibodies: Rheumatoid Factors (RhF) against Fc of IgG, and to citrullinated (Cit) protein/peptide sequences: ACPA, recognizing multiple Cit-sequences. B cell depletion therapy based on rituximab delivers good clinical responses in RA patients, particularly in the seropositive group, wi...

INTRODUCTION Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activation. We investigated the relationship between RANKL and ACPA in patients with early untreated rheumatoid arthritis (RA). METHODS Patients with newly diagnosed untreated RA...

1 CITEC, Bielefeld University, Germany [email protected] [email protected] [email protected] 2 Alexandru Ioan Cuza University of Iasi, Romania [email protected] 3 IBM Research, Dublin, Ireland [email protected] 4 AKSW, University of Leipzig, Germany [email protected] 5 INRIA Sophia-Antipolis Méditerrané, Cedex, France elena.cabrio@i...