OBJECTIVE We identified a poor clinical response to treatment of cholera with a single 1 g dose of ciprofloxacin, a standard treatment for cholera. METHODS To determine reasons for the poor response and better therapeutic approaches we examined the minimal inhibitor concentration (MIC, n = 275) and disc-diffusion zone sizes (n = 205) for ciprofloxacin and nalidixic acid of V. cholerae O1 stra...

Decreased susceptibility of Neisseria meningitidis isolates to ciprofloxacin emerged from an outbreak in Delhi, India. Results of antimicrobial susceptibility testing of the meningococcal isolates to ciprofloxacin and further sequencing of DNA gyrase A quinolone-resistance-determining region confirmed the emergence of ciprofloxacin resistance in the outbreak.

Following intravenous doses, ciprofloxacin pharmacokinetics in control and nephrectomized rats were studied. There were no differences between control and nephrectomized rats for area under the concentration-time curve in plasma or biliary clearance. The intestinal clearance of ciprofloxacin was increased in nephrectomized rats. Intestinal elimination seems to compensate partially for the decre...

This is the first report on the use of a normally lethal dose of ciprofloxacin in a Campylobacter agar medium to kill all ciprofloxacin-sensitive Campylobacter spp. but allow the selective isolation and quantitation of naturally occurring presumptive ciprofloxacin-resistant Campylobacter CFU in rinses from retail raw chicken carcasses (RTCC). Thermophilic-group total Campylobacter CFU and total...

OBJECTIVES For fluoroquinolones, the area under the free plasma concentration-time curve divided by the MIC (fAUC/MIC) best predicts bacterial killing in mice and outcomes in patients. However, it is unknown whether the shape of the antibiotic concentration profile affects resistance emergence. Our objective was to compare killing and resistance between ciprofloxacin concentration profiles with...

this study was designed to compare the efficacy of a phytobiotic containing a mixture of essential oils of oreganum aetheroleum and an antibiotic containing ciprofloxacin as an active principle for the treatment of experimental escherichia coli (e. coli) infection in broiler chickens. two-hundred-day-old broiler chickens were divided into 5 equal groups. the 1st group was neither challenged nor...

side effects of ciprofloxacin (cpfx), a widely used broad spectrum antibiotic with fluoroquinolone core, have been reported in different organs. in the present study we sought to elucidate the impact of ciprofloxacin on sperm chromatin integrity and sperm dna damage using aniline blue and acridine orange technique, respectively. the fertility potential in male mice was also evaluated. nmri male...

ingestion of ciprofloxacin can be associated with esophagitis and esophageal ulcer. we report a 46-yearold man with odynophagia and dysphagia following ciprofloxacin ingestion, with a glance on diagnosis and treatment. also, we propose recommendations for prevention of drug-induced esophagitis, according to shape, size, formulation and their etiologic role on esophagitis.

abstract objective fever and neutropenia are a common complication of chemotherapy in cancer. it is usually managed by hospitalization and empiric administration of antibiotics. use of fluroquinolones is limited because of joint/cartilage toxicity. this study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia....

background: ciprofloxacin is a commonly prescribed antibiotic in the treatment of genitourinary tract infection. objective: the aim of this study was to investigate the effects of ciprofloxacin on testis apoptosis and sperm parameters in rat. materials and methods: twenty male wistar rats were selected and randomly divided into two groups; control (n=10) and experimental (n=10). the experimenta...