Chorionic villus biopsy was performed in 20 cases scheduled for termination of pregnancy for social reasons, the average gestational age was 8.4 weeks with a range of seven to 11 weeks. The average time taken for the procedure starting from cleaning the vagina to identification of the villi under the dissecting microscope was 12.7 minutes with a range of five to 30 minutes. Chorionic villi mate...

We have recently shown using dansyl-L-lysine exclusion studies that the release of human chorionic gonadotrophin (HCG) in conjunction with L-lactate dehydrogenase (LDH) from first trimester villi during organ culture is symptomatic of syncytiotrophoblast degeneration. The purpose of this study was to examine chorionic villi at the ultrastructural level in order to determine events occurring dur...

We present two pregnancies associated with normal live births and the unusual concomitance of chorangioma and placental vascular malformation with mesenchymal hyperplasia. The enlarged placenta had the characteristic findings of chorangioma, dilated and varicose chorionic vessels and multiple vesicle-like villi containing hyaluronic acid. The vesicle-like villi showed diploid cellular DNA conte...

both cultured and uncultured chorionic villi were of fetal origin, (b) the 632C3T transition was heterozygous (Fig. 1B), and (c) the complex I enzyme activities were normal (Table 1). A healthy boy was born after an uncomplicated pregnancy. He is now 3 years of age and does not show any symptoms of mitochondrial disease. This case demonstrates the difficulties that can arise from prenatal diagn...

A study was performed to evaluate the effect on the frequency of sister chromatid exchange in first trimester chorionic villi of two chemical compounds, mitomycin C and cyclophosphamide. Mitomycin C is generally known to induce an increase in sister chromatid exchange both in vivo and in vitro standard conditions. Cyclophosphamide is a compound requiring additional enzymatic enrichment of the c...

Previous study demonstrated that IL-11 receptor alpha knockout female mice (IL-11Ralpha(-/-)) were phenotypically normal but infertile due to defective decidualization. However, the role of IL-11 signaling in human reproduction remains unclear. This study examined the expression of IL-11, IL-11Ralpha, and signal transduction factor glycoprotein 130 in different phases of endometrium (six in pro...

The study of placental lactogen by immunohistochemistry in histological sections the placenta during physiological pregnancy and on background iron deficiency anemia aspect chronic insufficiency. It is established that gestation against decreases production syncytiotrophoblast chorionic villi correlates with state blood pregnant woman. optical density immunohistochemical staining for free troph...

STUDY QUESTION Is there an association between chorionic villous vascularization, ultrasound findings and corresponding chromosome results in early miscarriage specimens from a cohort of recurrent pregnancy loss patients? SUMMARY ANSWER We did not find a significant difference in vascularization scores of chorionic villi between embryonic, yolk sac or empty sac miscarriages, or between euploi...

OBJECTIVE To assess the fetal loss rate following amniocentesis and chorionic villus sampling (CVS). METHODS This was a national registry-based cohort study, including all singleton pregnant women who had an amniocentesis (n = 32 852) or CVS (n = 31 355) in Denmark between 1996 and 2006. Personal registration numbers of women having had an amniocentesis or a CVS were retrieved from the Danish...

Current prenatal diagnosis for fetal aneuploidies (including trisomy 21 [T21]) generally relies on an initial biochemical serum-based noninvasive prenatal testing (NIPT) after which women who are deemed to be at high risk are offered an invasive confirmatory test (amniocentesis or chorionic villi sampling for a fetal karyotype), which is associated with a risk of fetal miscarriage. Recently, ge...