نتایج جستجو برای: chop

تعداد نتایج: 4508  

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 1998
F Celsing S Widell K Merk P Bernell G Grimfors A Hedlund J Liliemark E Svedmyr E Osby M Björkholm

BACKGROUND Second- and third-generation chemotherapy protocols for the treatment of aggressive non-Hodgkin's lymphomas (NHL) have considerable, and age-related, toxic effects. In addition, they do not seem to prolong overall survival in comparison to standard CHOP chemotherapy. In this phase II study we investigated the feasibility and efficacy of the addition of etoposide to the conventional C...

Journal: :Haematologica 2010
Jesse Shustik Guangming Han Pedro Farinha Nathalie A Johnson Susana Ben Neriah Joseph M Connors Laurie H Sehn Douglas E Horsman Randy D Gascoyne Christian Steidl

BACKGROUND BCL6 gene rearrangement is the most frequent chromosomal abnormality in diffuse large B-cell lymphoma, a malignancy characterized by genetic heterogeneity and wide variability in clinical outcome. The prognostic significance of BCL6 rearrangement has not been evaluated in the context of rituximab therapy for diffuse large B-cell lymphoma. We analyzed the effect of the BCL6 rearrangem...

Journal: :Blood 2016
Zijun Y Xu-Monette Ling Li John C Byrd Kausar J Jabbar Ganiraju C Manyam Charlotte Maria de Winde Michiel van den Brand Alexandar Tzankov Carlo Visco Jing Wang Karen Dybkaer April Chiu Attilio Orazi Youli Zu Govind Bhagat Kristy L Richards Eric D Hsi William W L Choi Jooryung Huh Maurilio Ponzoni Andrés J M Ferreri Michael B Møller Ben M Parsons Jane N Winter Michael Wang Frederick B Hagemeister Miguel A Piris J Han van Krieken L Jeffrey Medeiros Yong Li Annemiek B van Spriel Ken H Young

CD37 (tetraspanin TSPAN26) is a B-cell surface antigen widely expressed on mature B cells. CD37 is involved in immune regulation and tumor suppression but its function has not been fully elucidated. We assessed CD37 expression in de novo diffuse large B-cell lymphoma (DLBCL), and investigated its clinical and biologic significance in 773 patients treated with rituximab plus cyclophosphamide, do...

Journal: :Carcinogenesis 2006
Eun Mi Jung Jong-Wook Park Kyeong Sook Choi Jeen-Woo Park Hyung Il Lee Kyung-Seop Lee Taeg Kyu Kwon

Death receptor DR5 (DR5/TRAIL-R2) is an apoptosis-inducing membrane receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In this study, we showed that curcumin, a plant product containing the phenolic phytochemical, is a potent enhancer of TRAIL-induced apoptosis through upregulation of DR5 expression. Both treatment with DR5/Fc chimeric protein and silencing of DR5 exp...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1998
F Willeke R Ridder G Mechtersheimer M Schwarzbach A Duwe J Weitz T Lehnert C Herfarth M von Knebel Doeberitz

In myxoid and round cell liposarcomas, a specific chromosomal translocation [(12;16)(q13;p11)] results in the expression of chimeric fusion transcripts encompassing parts of the FUS gene (16p11) at their 5' ends and the CHOP gene (12q13) at their 3' ends. Using a reverse transcription-PCR protocol, we determined the prevalence of FUS-CHOP fusion transcripts in a series of liposarcoma samples. F...

Journal: :Neuron 2008
Maria Pennuto Elisa Tinelli MariaChiara Malaguti Ubaldo Del Carro Maurizio D'Antonio David Ron Angelo Quattrini M. Laura Feltri Lawrence Wrabetz

Deletion of serine 63 from P0 glycoprotein (P0S63del) causes Charcot-Marie-Tooth 1B neuropathy in humans, and P0S63del produces a similar demyelinating neuropathy in transgenic mice. P0S63del is retained in the endoplasmic reticulum and fails to be incorporated into myelin. Here we report that P0S63del is misfolded and Schwann cells mount a consequential canonical unfolded protein response (UPR...

Journal: :Biochemical and biophysical research communications 2006
Kanae Hyoda Toru Hosoi Naohiro Horie Yasunobu Okuma Koichiro Ozawa Yasuyuki Nomura

Stress signals that impair the function of the endoplasmic reticulum (ER) can lead to an accumulation of unfolded proteins in the ER causing cell death. Recent studies have indicated that ER stress contributes to several diseases such as neurodegenerative disorders or diabetes. In the present study, we found that Akt down-regulation is important for inducing CHOP expression, an ER stress-induce...

Journal: :Journal of virology 2004
Christopher L Netherton James C Parsley Thomas Wileman

Stress signaling from mitochondria and the endoplasmic reticulum (ER) leads to the induction of the proapoptotic transcription factor CHOP/GADD153. Many viruses use the ER as a site of replication and/or envelopment, and this activity can lead to the activation of ER stress and apoptosis. African swine fever virus (ASFV) is assembled on the cytoplasmic face of the ER and ultimately enveloped by...

2009
Peter Ebraert Andreas Classen Patrick Heymans Theo D'Hondt

The idea of feature-oriented programming is to map requirements to features, concepts that can be composed to form a software product. Change-oriented programming (ChOP), in which features are seen as sets of changes that can be applied to a base program, has recently been proposed as an approach to FOP. Changes are recorded as the programmer works and can encapsulate any developer action, incl...

Journal: :The heart surgery forum 2009
Hsiang-Yu Yang Hung-Yen Ke Gou-Jieng Hong Yi-Ting Tsai Chih-Yuan Lin Chung-Yi Li Chien-Sung Tsai

Posttransplantation lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation, with an incidence of 0.8% to 20% in heart transplant (HTx) recipients, and standard treatment may be too toxic in some cases. Rituximab is an anti-CD20 monoclonal antibody that has demonstrated efficacy in patients with various lymphoid malignancies and has been demonstrated effective in ...

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