The Kalow allele for cholinesterase is a quantitative variant of the usual gene and has been shown to result from a single base pair change in the DNA. A new method based on the polymerase chain reaction to distinguish Kalow alleles of the cholinesterase gene was developed. Using the amplification refractory mutagenesis system, two different reactions distinguished the presence of a guanine (no...

The activity of cholinesterase and some biochemical parameters of blood such as glucose, cholesterol and phospholipids were estimated in 52 epilepsy induced females of Wister albino rats. Animals of this experiment were divided into two groups, group (I) regarded as control and group (II) administrated subcutaneously by pentylenetetrazole 100mg/kg and divided in to three sub-groups according to...

Cholinesterase is widely distributed in the animal kingdom, but its function apart from its involvement in the process of cholinergic transmission is unknown. Recent evidence indicates a close association between lipids and cholinesterase. Hyperlipaemia in humans.(Cucuinau etal., 1968)andrabbits (Kutty etal., 1973) is associated with increased serum cholinesterase activity. Cholinesterase has b...

alzheimer’s disease (ad) is a neurodegenerative disease that was characterized with deposit of beta amyloid (aβ) aggregate in senile plaque. oxidative damage to neurons and loss of cholinergic neurons in forebrain region are observed in this disease. melissa officinalis is a medicinal plant from lamiaceae family, used traditionally in the treatment of cognitive disorders. it has cholinomimetic ...

The cholinesterase inhibitors donepezil, rivastigmine and galantamine have a modest and transient benefit in Alzheimer's disease. Their known adverse effects include bradycardia. A Canadian case-control study conducted between 2003 and 2008 showed a statistically significant increase in the risk of hospitalisation for bradycardia among patients who had been taking a cholinesterase inhibitor for...

The cholinergic dysfunction in AD is not necessarily predominant (1,4,5) and responsivity to a cholinesterase inhibitor is not diagnostic for Alzheimer’s disease. Normal young people have improved on psychometric measures in memory and attention after physostigmine challenge (3). Additionally, postmortem neurochemical measures of cholinergic function in AD patients do not correlate with ante mo...

Cholinesterase was purified from human serum by a three-stage procedure involving chromatography on DEAE-cellulose at pH4.0, an electrofocusing technique and gel filtration on Sephadex G-200. The final product was purified 13000-fold with a yield of 54%, and only one protein and one cholinesterase band could be demonstrated by polyacrylamide-disc electrophoresis. The catalytic properties appear...

Enzymes hydrolysing acetylcholine have attracted much attention because acetylcholine is concemed with the functioning of the nervous system. The extensive literature on cholinesterases has been reviewed at intervals (Zeller, 1948; Koelle & Gilman, 1949; Augustinsson, 1950; Nachmansohn & Wilson, 1951; Whittaker, 1951; Davies, 1954; Bergmann, 1958; Davies & Green, 1958). Although there is ample ...

A novel agarofuran sesquiterpene polyol ester, 1beta,2beta,6alpha,15beta-tetracetoxy-8 beta,9alpha-dibenzoyloxy-beta- dihydroagarofuran (celahin D) (1), two known analogues of 1,1beta-acetoxy-8beta,9alpha-dibenzoyloxy-4al pha6alpha-dihydroxy-2beta(alphamethylbutanoyloxy)-beta-++ +dihydroagarofuran (2) and beta-acetoxy-8beta,9alpha-dibenzoyloxy-6alpha-hy droxy-2beta(alpha -methylbutanoyloxy)-bet...

In the present study, a series of N-substituted derivatives of 2-phenylethylamine has been synthesized. The reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded N-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). These derivatives were cha...