نتایج جستجو برای: chlorothiazide
تعداد نتایج: 203 فیلتر نتایج به سال:
THE effectiveness of ehlorothiazide and related compounds as diuretics and antihypertensive agents has been well established. Much confusion still exists, however, regarding the exact mechanisms by which these ag,ents reduce arterial pressure. Although it has not been fully established whether the reduction in arterial pressure following the thiazides is due solely to sodium diuresis,1 is secon...
Ethacrynic acid (MK-595) 1 is a new orally active saluretic agent structurally unrelated to organomercurial or benzothiadiazine diuretics (2). Its biological properties in experimental animals were first studied by Baer, Russo, Michaelson, and Beyer (3, 4), who reported it to be a natriuretic drug more potent than chlorothiazide and suggested that it might have a novel mode of action. Clinicall...
A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations. However, unlike other children with hyperinsulinism, this patient had a persistently elevated blood spot hydroxybutyrylcarnitine concentration when fed, as well as when ...
The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the action of drugs. To elucidate the molecular mechanisms for the tubular excretion of diuretics, we have elucidated the interactions of human organic anion transporters (hOATs) with diuretics using cells stably expressing hOATs. Diuretics tested were thiazides, including chlorothiazide, cyclothiazide, ...
RATIONALE Compound 21 (C-21) is a highly selective nonpeptide angiotensin AT2 receptor (AT2R) agonist. OBJECTIVE To test the hypothesis that chronic AT2R activation with C-21 induces natriuresis via an action at the renal proximal tubule (RPT) and lowers blood pressure (BP) in experimental angiotensin II (Ang II)-dependent hypertension. METHODS AND RESULTS In rats, Ang II infusion increased...
Thiazides block Na+ reabsorption while enhancing Ca2+ reabsorption in the kidney. As previously demonstrated in immortalized mouse distal convoluted tubule (MDCT) cells, chlorothiazide application induced a robust plasma membrane hyperpolarization, which increased Ca2+ uptake. This essential thiazide-induced hyperpolarization was prevented by the Cl- channel inhibitor 5-Nitro-2-(3-phenylpropyla...
Thiazide diuretics are specific inhibitors of the Na-Cl cotransporter in the distal convoluted tubule (DCT). In addition to producing diuresis and natriuresis, they have a hypocalciuric effect. Recently, two apical calcium channels have been identified, transient receptor potential vanilloid 5 (TRPV5) and TRPV6; both are expressed in the DCT. We studied the effects of thiazides on mouse renal c...
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