BACKGROUND Diets high in carbohydrates may result in chronically elevated insulin concentrations and may affect breast cancer risk by stimulation of insulin receptors or through insulin-like growth factor I (IGF-I)-mediated mitogenesis. Insulin response to carbohydrate intake is increased in insulin-resistant states such as obesity. OBJECTIVE We sought to evaluate carbohydrate intake, glycemi...

To investigate the effects of fat and carbohydrate on appetite, food intake and gastric emptying with and without the influence of orosensory factors, a group of nine healthy, fasted male subjects took part in two separate paired experiments involving high-fat and high-carbohydrate radiolabelled soup preloads. In the first experiment subjects received direct intragastric isocaloric infusions of...

The relative contribution of nutrition-related chronic diseases to the total disease burden of the society and the health care costs has risen continuously over the last decades. Thus, there is an urgent necessity to better exploit the potential of dietary prevention of diseases. Carbohydrates play a major role in human nutrition – next to fat, carbohydrates are the second biggest group of ener...

The adaptive modulation hypothesis posits that the expression of digestive proteins should be modulated in response to intake of their respective substrates. A corollary of this hypothesis suggests that dietary flexibility and digestive plasticity should be correlated. We examined these two hypotheses in two granivorous Chilean birds (Zonotrichia capensis and Diuca diuca) that differ in dietary...

Obesity is a worldwide epidemic and will be followed by a worldwide epidemic of diabetes. While diet, lifestyle, and exercise are the cornerstones of current approaches to treat obesity, they have been ineffective in stemming the current epidemic. In this issue of THE JOURNAL, the article by Bravata et al systematically reviews and synthesizes the literature on the use of low-carbohydrate diets...

Non-alcoholic fatty liver disease (NAFLD) is closely associated with insulin resistance and obesity. Hence, carbohydrate quality could be of relevance to the risk of NAFLD, but prospective data are lacking. The aim of the present study was to investigate longitudinal associations between carbohydrate quality (including dietary glycaemic index (GI) and intakes of sugar, starch and fibre) and mar...

BACKGROUND/AIMS The genetic basis for ingestive behaviors is virtually unknown. Quantitative trait loci (QTLs) for carbohydrate and energy intake map to mouse chromosome 17 and were previously confirmed by a congenic strain bearing CAST/Ei (CAST) donor segment on the C57BL/6J (B6) background. METHODS We used microarray technology to facilitate gene identification. Gene expression was compared...

OBJECTIVE The effects of dietary macronutrient composition on metabolic profiles in patients with type 2 diabetes have been inconsistent. This meta-analysis aimed to elucidate the effect of replacing dietary fat with carbohydrate on glucose and lipid parameters in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS We searched for randomized trials that investigated the effects of two ...

Muscle glycogen, the predominant form of stored glucose in the body, and blood glucose are the main energy substrates for muscle contraction during exercise. Sucrose is an ideal substance for athletes to incorporate because it provides both glucose and fructose. Therefore, it is essential that athletes monitor their diet to maintain and increase muscle glycogen deposits, since they are a major ...

In the present study the relationship of sugar-sweetened beverage (SSB) consumption with the intake of single nutrients and total diet quality in German children and adolescents was evaluated using a repeated-measures regression analysis model. We used dietary data from 7145 three-day weighed records of 1069 subjects aged 2-19 years participating in the Dortmund Nutritional and Anthropometric L...