نتایج جستجو برای: calpain gene

تعداد نتایج: 1145038  

2011
Ji C Jeong Won Y Shin Thae H Kim Chae H Kwon Jae H Kim Yong K Kim Ki H Kim

BACKGROUND Silibinin, a natural polyphenolic flavonoid, has been reported to induce cell death in various cancer cell types. However, the molecular mechanism is not clearly defined. Our previous study showed that silibinin induces glioma cell death and its effect was effectively prevented by calpain inhibitor. The present study was therefore undertaken to examine the role of calpain in the sili...

Journal: :Cardiovascular research 2012
Matthew A Smith Rick G Schnellmann

Mitochondrial activity is critical for efficient function of the cardiovascular system. In response to cardiovascular injury, mitochondrial dysfunction occurs and can lead to apoptosis and necrosis. Calpains are a 15-member family of Ca(2+)-activated cysteine proteases localized to the cytosol and mitochondria, and several have been shown to regulate apoptosis and necrosis. For example, in endo...

Journal: :The Journal of Cell Biology 1993
J E Fox R G Taylor M Taffarel J K Boyles D E Goll

Calpain (a Ca(2+)-dependent protease) is present in many cell types. Because it is present in the cytosol, the potential exists that it may regulate critical intracellular events by inducing crucial proteolytic cleavages. However, the concentrations of Ca2+ required to activate calpain are higher than those attained in the cytoplasm of most cells. Thus, the physiological importance of calpain a...

Journal: :Investigative ophthalmology & visual science 1992
M Azuma R S Anderson S Sameshima T Matsumoto L L David T R Shearer

This study was conducted to provide a description of calpain proteolytic enzyme (EC 3.4.22.17) in normal rat cornea and to document immunohistochemical changes in calpain distribution during maturation. Corneal soluble proteins were fractionated by diethylaminoethyl chromatography on high-performance liquid chromatography. Fractions were analyzed for calpain by enzyme-linked immunosorbent assay...

2012
Matthew A. Smith Rick G. Schnellmann

Mitochondrial activity is critical for efficient function of the cardiovascular system. In response to cardiovascular injury, mitochondrial dysfunction occurs and can lead to apoptosis and necrosis. Calpains are a 15-member family of Ca2+-activated cysteine proteases localized to the cytosol and mitochondria, and several have been shown to regulate apoptosis and necrosis. For example, in endoth...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Yoshiro Yoshikawa Hiroji Hagihara Yoshimi Ohga Chikako Nakajima-Takenaka Ken-ya Murata Shigeki Taniguchi Miyako Takaki

We hypothesized that calpain inhibitor-1 protected left ventricular (LV) function from ischemia-reperfusion injury by inhibiting the proteolysis of alpha-fodrin. To test this hypothesis, we investigated the effect of calpain inhibitor-1 on LV mechanical work and energetics in the cross-circulated rat hearts that underwent 15-min global ischemia and 60-min reperfusion (n = 9). After ischemia-rep...

2015
Bin Xu Wei Liu Yu Deng Tian-Yao Yang Shu Feng Zhao-Fa Xu

Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear. To explore whether alpha-synuclein oligomerization was associated with the cleavage of alpha-synuclein by calpain, we made a rat brain slice model of manganism and pretreated slices with calpain ...

Journal: :American journal of physiology. Heart and circulatory physiology 2006
Karni S Moshal Mahavir Singh Utpal Sen Dorothea Susanne E Rosenberger Brooke Henderson Neetu Tyagi Hong Zhang Suresh C Tyagi

Hyperhomocysteinemia (HHcy) is associated with atherosclerosis, stroke, and dementia. Hcy causes extracellular matrix remodeling by the activation of matrix metalloproteinase-9 (MMP-9), in part, by inducing redox signaling and modulating the intracellular calcium dynamics. Calpains are the calcium-dependent cysteine proteases that are implicated in mitochondrial damage via oxidative burst. Mito...

Journal: :Journal of neurochemistry 2004
Jason D Hinman James A Duce Robert A Siman William Hollander Carmela R Abraham

Ultrastructural disruption of myelin sheaths and a loss of myelin with age are well-documented phenomena in both the human and rhesus monkey. Age-dependent activation of calpain-1 (EC 3.4.22.52) has been suggested as a plausible mechanism for increased proteolysis in the white matter of the rhesus monkey. The present study documents activation of calpain-1 throughout brain white matter in aged ...

2018
Michael P Marciel Aaron H Rose Verena Martinez David T Horio Ann S Hashimoto FuKun W Hoffmann Pietro Bertino Peter R Hoffmann

Calpain-2 levels are higher in colorectal tumors resistant to chemotherapy and previous work showed calpain-2 inhibitor therapy reduced inflammation-driven colorectal cancer, but direct effects of the inhibitor on colon cancer cells themselves were not demonstrated. In the present study, five human colon cancer cell lines were directly treated with a calpain-2 inhibitor and results showed incre...

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