BACKGROUND It is generally understood that postoperative C5 palsy can occur with anterior or posterior decompression surgery, but functional measures of the palsy have not been well documented. This study aimed to investigate the incidence of C5 palsy in different surgical procedures, examine the correlations between muscle strength, upper extremity functional measures, and health-related quali...

Fibrogenesis represents the universal response of the liver to chronic liver injury. Complement factor C5 has been linked to fibrosis in murine toxic liver injury and human chronic hepatitis C. C5 may also play a central role in chronic cholestatic disorders, since the BA receptor FXR has been characterized as an activator of the C3 gene. We aimed to investigate, whether C5 deficiency is able t...

Straw incorporation has a variety of impacts on greenhouse gas (GHG) emissions. However, few studies have focused the effects multi-year straw incorporation. In this study, field experiment was established to study and water-saving irrigation GHG emissions in cold region Northeast China. The following four treatments were included: (i) controlled (CI) with 1-year (C1), (ii) 5-year (C5), (iii) f...

We report a delayed postoperative injury to the esophagus in patient who underwent cervical corpectomy for spondylodiscitis. The was 72-year-old man. He diagnosed by magnetic resonance imaging with spondylodiscitis at C5/6/7, an epidural abscess and ossification of posterior longitudinal ligament from C2 C7. For surgical treatment, interbody fusion mesh cage C5/6, anterior plate laminectomy C3/...

OBJECTIVE Ischemic heart disease is the leading cause of death worldwide. The complement system plays a major role in inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R) injury. Systemic C5 inhibition in clinical studies has resulted in mixed results and the role of earlier complement components (e.g., C3a), upstream from C5 cleavage, has not been elucidated for ...

We want you to consider in detail the paper published in the January 2013 issue of Journal of Clinical Biochemistry and Nutrition, by Tomoki Aomatsu et al. entitled “Neutralization of complement component C5 ameliorates the development of dextran sulfate sodium (DSS)-colitis in mice”. The authors have evaluated the pathophysiological role of the complement system in a mice colitis model. To stu...

A high-resolution crystal structure is reported for d(TpA)*, the intramolecular thymine-adenine photoadduct that is produced by direct ultraviolet excitation of the dinucleoside monophosphate d(TpA). It confirms the presence of a central 1,3-diazacyclooctatriene ring linking the remnants of the T and A bases, as previously deduced from heteronuclear NMR measurements by Zhao et al. (The structur...

The UV photolysis of 8-bromo-2'-deoxyadenosine has been investigated in different solvents and in the presence of additives like halide anions. Photolytic cleavage of the C-Br bond leads to formation of the C8 radical. In methanol, subsequent hydrogen abstraction from the solvent is the main radical reaction; however, in water or acetonitrile intramolecular hydrogen abstraction from the sugar m...

Cobra venom factor (CVF) is a complement activating protein in cobra venom, which functionally resembles C3b, and has been used for decades for decomplementation of serum to investigate the role of complement in many model systems of disease. The use of CVF for clinical practice is considered impractical because of immunogenicity issues. Humanization of CVF was recently demonstrated to yield a ...