The downstream effector of PI3K, Akt, is frequently hyperactivated in human cancers. A critical downstream effector of Akt, which contributes to tumorigenesis, is mTOR. In the PI3K/Akt/mTOR pathway, Akt is flanked by two tumor suppressors: PTEN, acting as a brake upstream of Akt, and TSC1/TSC2 heterodimer, acting as a brake downstream of Akt and upstream of mTOR. In the absence of the TSC1/TSC2...

Brake fluid is a mixture of different Glycol derivatives which are poisoning and their ingestion triggers significant CNS symptoms, severe metabolic acidosis, cardiac, pulmonary, and renal failure. Here in this study, a case is reported who had been ingested 150mL of brake fluid for suicidal attempt.

Passive haptic displays have several advantages when compared to active devices. Safety elements associated with active haptic displays may make them undesirable for certain applications. One method of actuation for passive haptic robots is through the use of brakes and clutches. Traditionally, friction brakes have undesirable behavior, such as stiction and delay in response time due to mechani...

A tabletop waterwheel, designed and built by Prof. Willem Malkus (Math. Dept., MIT), is used to demonstrate chaos in a mechanical analog of the Lorenz equations. The waterwheel’s rotational damping rate can be adjusted by tightening or loosening a brake. When the brake is not too tight, the wheel settles into a steady rotation. Either direction of rotation is possible. When the brake was tighte...

The aim of the study was to create a model, describing the run of tribological processes in the surface layer of grey cast iron automotive brake discs. Grey cast iron discs mating with non-asbestos organic brake pads were chosen for the investigations, as the most widely used materials in car brakes. Samples for surface analysis were prepared from disc operating in stand and road conditions. St...

Traffic-related sources have been recognized as a significant contributor of particulate matter particularly within major cities. Exhaust and non-exhaust traffic-related sources are estimated to contribute almost equally to traffic-related PM10 emissions. Non-exhaust particles can be generated either from non-exhaust sources such as brake, tyre, clutch and road surface wear or already exist in ...

Interest in the field of human-centered robotics continues to grow, particularly in utilizing pneumatic artificial muscles (PAMs) for close human–robot collaborations. Addressing the limited control performance of PAMs, we proposed a hybrid actuation scheme that combines PAMs (macro) and a low-inertia DC motor (mini). While the scheme has shown significantly improved control performance and rob...

in this study it has been tried, to compare results and convergence rate of sensitivity analysis and conjugate gradient algorithms to reduce fuel consumption and increasing engine performance by optimizing the timing of opening and closing valves in xu7/l3 engine. in this study, considering the strength and accuracy of simulation gt-power software in researches on the internal combustion engine...