نتایج جستجو برای: blocked voltage

تعداد نتایج: 158911  

Journal: :Journal of neurophysiology 2008
Andreas Husch Simon Hess Peter Kloppenburg

Toward our goal to better understand the physiological parameters that mediate olfactory information processing on the cellular level, voltage-activated calcium currents (I(Ca)) in olfactory interneurons of the antennal lobe from adult cockroaches were analyzed under two conditions: 1) in acutely dissociated cells (in vitro) and 2) in an intact brain preparation (in situ). The study included an...

Journal: :The Journal of physiology 2002
Hua Hu Koen Vervaeke Johan F Storm

Coherent network oscillations in the brain are correlated with different behavioural states. Intrinsic resonance properties of neurons provide a basis for such oscillations. In the hippocampus, CA1 pyramidal neurons show resonance at theta (theta) frequencies (2-7 Hz). To study the mechanisms underlying theta-resonance, we performed whole-cell recordings from CA1 pyramidal cells (n = 73) in rat...

Journal: :American journal of physiology. Renal physiology 2010
Zhong Zhang Hai Lin Chunhua Cao Sandeep Khurana Thomas L Pallone

Multiple voltage-gated Ca(2+) channel (Ca(V)) subtypes have been reported to participate in control of the juxtamedullary glomerular arterioles of the kidney. Using the patch-clamp technique, we examined whole cell Ca(V) currents of pericytes that contract descending vasa recta (DVR). The dihydropyridine Ca(V) agonist FPL64176 (FPL) stimulated inward Ca(2+) and Ba(2+) currents that activated wi...

2008
Andreas Husch Simon Hess Peter Kloppenburg

Husch A, Hess S, Kloppenburg P. Functional parameters of voltageactivated Ca currents from olfactory interneurons in the antennal lobe of Periplaneta americana. J Neurophysiol 99: 320–332, 2008. First published November 14, 2007; doi:10.1152/jn.00719.2007. Toward our goal to better understand the physiological parameters that mediate olfactory information processing on the cellular level, volta...

2013
Nebojsa Kezunovic James Hyde Belen Goitia Veronica Bisagno Francisco J. Urbano Edgar Garcia-Rill

We previously reported that persistent application of the non-specific cholinergic agonist carbachol (CAR) increased the frequency of calcium channel-mediated oscillatory activity in pedunculopontine nucleus (PPN) neurons, which we identified as dependent on voltage-gated, high-threshold P/Q-type channels. Here, we tested the hypothesis that M2 muscarinic receptors and G-proteins associated wit...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
A Akopian J Johnson R Gabriel N Brecha P Witkovsky

We investigated the cellular localization in the salamander retina of one of the somatostatin [or somatotropin release-inhibiting factor (SRIF)] receptors, sst(2A), and studied the modulatory action of SRIF on voltage-gated K(+) and Ca(2+) currents in rod and cone photoreceptors. SRIF immunostaining was observed in widely spaced amacrine cells, whose perikarya are at the border of the inner nuc...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
D L Sodickson B P Bean

GABA and the GABAB receptor agonist baclofen activated a potassium conductance in acutely dissociated hippocampal CA3 neurons. Baclofen-activated current required internal GTP, was purely potassium selective, and showed strong inward rectification. As with acetylcholine-activated current in atrial myocytes, external Cs+ blocked inward but not outward current in a highly voltage-dependent manner...

Journal: :Molecular pharmacology 1997
M C Sanguinetti J H Johnson L G Hammerland P R Kelbaugh R A Volkmann N A Saccomano A L Mueller

Toxins isolated from scorpion, snake, and spider venoms are valuable tools to probe the physiologic function and structure of ion channels. In this study, we have isolated three new toxins (heteropodatoxins) from the venom of a spider, Heteropoda venatoria. These toxins are structurally similar peptides of 29 to 32 amino acids and share sequence homology with hanatoxins isolated from the venom ...

Journal: :Neuroscience research 2013
Armando Alberola-Die Antonio Reboreda J Antonio Lamas Andrés Morales

Lidocaine is a commonly used local anaesthetic that, besides blocking voltage-dependent Na(+) channels, has multiple inhibitory effects on muscle-type nicotinic acetylcholine (ACh) receptors (nAChRs). In the present study, we have investigated the effects of lidocaine on ACh-elicited currents (IAChs) from cultured mouse superior cervical ganglion (SCG) neurons, which mainly express heteromeric ...

Journal: :Circulation research 1991
J Y Wu J Vereecke E Carmeliet S L Lipsius

Whole-cell recording techniques were used on single right atrial myocytes to study the ionic currents that may be responsible for the diverse diastolic voltage characteristics of atrial tissue. Ionic currents were activated by hyperpolarizing voltage pulses negative to -30 mV. In general, four different types of cells were identified based primarily on the ionic currents elicited during hyperpo...

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