Cloud computing has emerged rapidly as an exciting new paradigm that offers a challenging model of computing and services. Leveraging cloud computing technology, bioinformatics tools can be made available as services to anyone, anywhere, and through any device. The use of large biodatasets, its highly demanding algorithms, and the hardware for sudden computational resources makes large-scale bi...

The manipulation of biological substrates is becoming more popular route towards generating novel computing devices. Physarum polycephalum is used as a model organism in biocomputing because it can create ‘wires’ for use in hybrid circuits; programmable growth by manipulation through external stimuli and the ability withstanding a current and its tolerance to hybridisation with a variety of nan...

Word and language operations on trajectories provide a general framework for the study of properties of sequential insertion and deletion operations. A trajectory gives a syntactical constraint on the scattered insertion (deletion) of a word into(from) another one, with an intuitive geometrical interpretation. Moreover, deletion on trajectories is an inverse of the shuffle on trajectories. Thes...

Biological systems are collections of discrete molecular objects that move around and collide with each other. Cells carry out elaborate processes by precisely controlling these collisions, but developing artificial machines that can interface with and control such interactions remains a significant challenge. DNA is a natural substrate for computing and has been used to implement a diverse set...

We report an experimental evaluation of the "input-output surface" for a biochemical AND gate. The obtained data are modeled within the rate-equation approach, with the aim to map out the gate function and cast it in the language of logic variables appropriate for analysis of Boolean logic for scalability. In order to minimize "analog" noise, we consider a theoretical approach for determining a...

This marks the first time that the Pacific Symposium in Biocomputing has hosted a session specifically devoted to the emerging computational needs of metabolomics. Metabolomics, or metabonomics as it is sometimes called, is a relatively new field of “omics” research concerned with the high-throughput identification and quantification of the small molecule metabolites in the metabolome (i.e. the...

It has been recently proposed that the matter-antimatter asymmetry of the universe may have its origin in “post-sphaleron baryogenesis” (PSB). It is a TeV scale mechanism that is testable at the LHC and other low energy experiments. In this paper we present a theory of PSB within a quark-lepton unified scheme based on the gauge group SU(2)L ×SU(2)R × SU(4)c that allows a direct connection betwe...

Social media platforms are emerging digital communication channels that provide an easy way for common people to share their health and medication experiences online. With more people discussing their health information online publicly, social media platforms present a rich source of information for exploring adverse drug reactions (ADRs). ADRs are major public health problems that result in de...

the purpose of annotation for 3D model is that it can automatically list the best suitable labels to describe the 3D models; it is an important part of the text-based 3D model retrieval. The existence of the semantic gap makes the result based on the similarity matching techniques needs to be improved. In order to improve the 3D model annotation performance using a large number of unlabeled sam...