Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found...

introduction: this study was designed to investigate the effects of music in wistar rats after sub-chronic treatment of simvastatin. the rats were orally administered with either simvastatin or saline (controls). after 4 weeks of drug treatment, the rats were selected for behavioral studies. the rats were exposed to music 24 hours before behavioral tests (mozart’s piano sonata, kv361, largo). r...

aim and background: the role of behavioral inhibition and activation systems as predisposing factors in readiness for emotional and behavioral problems in adolescents has been increasingly studied in recent years. the purpose of this study was to investigate the role of these two systems in predicting the development of psychopathology in adolescents. methods and materials: the study population...

Few studies to date have cross-validated indicators of malingering that have been suggested on various neuropsychological tests. This study presents data cross-validating several indicators of malingering on neuropsychological tests, as well as on tests of malingering and via behavioral observations. It incorporates methodological recommendations by Rogers [Researching dissimulation. In: R. Rog...

Few data are available on adolescent users because most behavioral studies on anabolic-androgenic steroids (AAS) abuse have been performed in adults. Studies evaluating the impact of long-term effects of AAS abuse on the prepubertal phase are even more uncommon. Accordingly, this study was developed to test the hypothesis that changes induced by the use of AAS during the adolescent phase may be...

The psychotomimetic effects of N-methyl-d-aspartate receptor (NMDA) antagonists such as ketamine and phencyclidine suggest a role for reduced NMDA receptor-mediated neurotransmission in schizophrenia. GluN1 'hypomorph' (GluN1(hypo) ) mice exhibit reduced NMDA receptor expression and have been suggested as a mouse model of schizophrenia. However, NMDA receptors are ubiquitous and are implicated ...

background: the present study investigated the effects of gallic acid (ga) administration on trimethyltin chloride (tmt) induced anxiety, depression, and hippocampal neurodegeneration in rats. materials and methods: in this experimental study, the rats received intraperitoneal (i.p.) injections of tmt (8 mg/kg). the animals received either ga (50, 100 and 150 mg/kg) or saline as the vehicle for...