Background: Cellular level of enzyme activity can serve as a reliable biomarker in the event of environmental/chemical insults. Objectives: The present study investigated time-dependent alterations of erythrocyte glutathione S-transferase (Ery-GST) activity of non-malarious guinea pigs (Cavia tschudii) administered with pyrimethamine/sulfadoxine and artemether/lumefantrine combination therapies...

BACKGROUND Timor-Leste changed its malaria treatment protocol in 2007, replacing the first-line for falciparum malaria from sulphadoxine-pyrimethamine to artemether-lumefantrine. This study explored the factors affecting the implementation of the revised treatment protocol, with an emphasis on identifying key constraints. METHODS A mixed method approach drew on both qualitative and quantitati...

Aminoglycosides Amikacin Framycetin Sulphate Gentamicin Sulphate Kanamycin Sulphate Lincomycin Neomycin Spectinomycin Tobramycin PET imaging tracer FDG Macrolide antibiotics Azithromycin Azaerythromycin Clarithromycin Erythromycin Roxithromycin Bioanalysis of pharmaceutics Acetaminophen Artemisinin Dihydro-artemisinin Artemether Etoposide 8-OH-DPAT mesna BNP7787 Vincristine Application Note Bio...

GABA and the antimalarial drug artemether, which acts on GABAergic pathways, can drive pancreatic cells with an α-cell phenotype toward a β-cell-like phenotype. As reported in two papers (Ben-Othman et al. and Li et al.), these drugs can stimulate the production of sufficient numbers of new β-like cells to reverse severe diabetes in mice.

The recent study of the traditional medicines in China has given us confidence that what was recorded in Chinese ancient medical literature through empirical observations is indeed still coincident with modem chemistry, pharmacology and medicine. An antimalarial drug, artemether, and an acetylcholinesterase inhibitor, huperzine A, are exemplified.

Assessment of the therapeutic efficacy of a paediatric formulation of artemether-lumefantrine (Co-artesiane(R)) for the treatment of uncomplicated Plasmodium falciparum in children in Zambia Malaria Journal 2006, 5:75 doi:10.1186/1475-2875-5-75 Pascalina Chanda ([email protected]) Moonga Hawela ([email protected]) Naawa Sipilanyambe ([email protected]) Mabvuto Kango ([email protected])

BACKGROUND Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea. METHODS Between April 2005 and July 2007, we conducted an open-label, randomized, parallel-group study of conventional chloroquine-sulfadoxine-pyrimethamine and artesunate-sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine, and artemether-l...

The in vitro cardiac properties of dihydroartemisinin (DHA) plus piperaquine phosphate (PQP) were compared with those of other antimalarial compounds. Results with antimalarial drugs, chosen on the basis of their free therapeutic maximum concentration in plasma (C(max)), were expressed as the fold of that particular effect with respect to their C(max). The following tests were used at 37 °C: hE...