To accelerate the molecular analysis of behavior in the honey bee (Apis mellifera), we created expressed sequence tag (EST) and cDNA microarray resources for the bee brain. Over 20,000 cDNA clones were partially sequenced from a normalized (and subsequently subtracted) library generated from adult A. mellifera brains. These sequences were processed to identify 15,311 high-quality ESTs represent...

The constant improvement and falling prices of whole human genome Next Generation Sequencing (NGS) has resulted in rapid adoption of genomic information at both clinics and research institutions. Considered together, the complexity of genomics data, due to its large volume and diversity along with the need for genomic data sharing, has resulted in the creation of Application Programming Interfa...

We have determined distinct roles for different proteasome complexes in adenovirus (Ad) E1A-dependent transcription. We show that the 19S ATPase, S8, as a component of 19S ATPase proteins independent of 20S (APIS), binds specifically to the E1A transactivation domain, conserved region 3 (CR3). Recruitment of APIS to CR3 enhances the ability of E1A to stimulate transcription from viral early gen...

Greater virtual machine density ............................................................................................................. 3 Performance and reliability features ................................................................................................... 4 Queue depth throttling ..............................................................................................

Conventionally, damaged and ubiquitinated proteins are subjected to degradation in the 26S proteasome in eukaryotes. However, several observations have indicated that the 19S subcomplex of the 26S proteasome may play a non-proteolytic role in RNA polymerase II (Pol II) transcription 1 : (1) Ubiquitination was thought to be required for activity of a viral transcription activator, VP16. (2) The ...

Aiming to contribute drug pre-formulation, new eutectic mixtures were developed. Thymol, coumarin, or quaternary ammonium chlorides as excipients, combined with the active pharmaceutical ingredients (APIs) acetylsalicylic acid, acetaminophen, ibuprofen, ketoprofen, lidocaine. Their solid-liquid equilibrium (SLE) binary phase diagrams measured study eventual separation between compounds, prevent...

We report novel API attacks on a Captcha web service, and discuss lessons that we have learned. In so doing, we expand the horizon of security APIs research by extending it to a new setting. We also show that system architecture analysis is useful both for identifying vulnerabilities in security APIs and for fixing them.