نتایج جستجو برای: antimycobacterial activity
تعداد نتایج: 1135098 فیلتر نتایج به سال:
Abstract Tuberculosis (TB) is a persistent lung infection caused by Mycobacterium tuberculosis . The disease characterized high mortality rates of over 1 million per year. Unfortunately, the potency and effectiveness currently used anti-TB drugs gradually decreasing due to constant development persistence resistance M. adverse side effects associated with current drugs, along drug resistance, p...
T-cell clones were established from Mycobacterium tuberculosis-immunized mice. These clones had the phenotype Thy-1+ L3T4+ Lyt-2- and were restricted by the H-2I-A locus. After antigen stimulation, the T-cell clones secreted interleukin-2 and gamma interferon. Factors produced by these T-cell clones activated normal bone marrow macrophages for antimycobacterial activity in vitro. Furthermore, t...
A combinatorial library composed of eleven hydrazides A-K and eleven indolin-1,2-dione derivatives 1-11 has been designed to formally generate sublibraries of 22 mixtures, M(1)-M(22) comprising of 121 Schiff bases, A-K(1-11). The designed library has been synthesized by the solution-phase method and microwave-assisted synthetic techniques. The formation of individual compounds of each mixture w...
Introduction Tuberculosis a major cause of death worldwide, is an infectious disease caused by Mycobacterium tuberculosis. An increase in drug-resistant tuberculosis cases and the emergence of additional resistant strains and coinfections with HIV has stimulated the search for and development of new anti-TB drugs [1]. The wide variety of natural products chemical structures plays a major role o...
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