ATP binding cassette (ABC) transporters, which are found in all species, are known mainly for their ability to confer drug resistance. To date, most of the ABC transporters characterized in plants have been localized in the vacuolar membrane and are considered to be involved in the intracellular sequestration of cytotoxins. Working on the assumption that certain ABC transporters might be involv...

The focus of this study was to isolate and to identify the actinomycetes having antimicrobial activity. A total of 145 actinomycetes were recovered from soil samples collected from different areas in Tamilnadu, India. All these isolates were screened for their antimicrobial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Klebsiella pneumonia and Candida albican...

Leptomycin B (LMB), a secondary metabolite produced by Streptomyces sp. strain ATS 1287, with known antifungal and antitumor effects, inhibits the nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 regulatory protein Rev and exhibits significant antiproliferative activity. Since LMB itself turned out to be distinctly cytotoxic, a bioconversion screening with a selected ...

Secondary metabolites have a great potential as pharmaceuticals, but there are only a few examples where regulation of gene cluster expression has been correlated with ecological and physiological relevance for the producer. Here, signals, mediators, and biological effects of terrein production were studied in the fungus Aspergillus terreus to elucidate the contribution of terrein to ecological...

Stable multipartite mutualistic associations require that all partners benefit. We show that a single mutational step is sufficient to turn a symbiotic bacterium from an inedible but host-beneficial secondary metabolite producer into a host food source. The bacteria's host is a "farmer" clone of the social amoeba Dictyostelium discoideum that carries and disperses bacteria during its spore stag...

Janthinobacterium and Duganella are well-known for their antifungal effects. Surprisingly, almost nothing is known on molecular aspects involved in the close bacterium-fungus interaction. To better understand this interaction, we established the genomes of 11 Janthinobacterium and Duganella isolates in combination with phylogenetic and functional analyses of all publicly available genomes. Ther...

The entire globe is reeling under the magnitude of current corona virus pandemic. This menace has proposed severe health and economic threats for all, thereby challenging our human existence itself. Since its outbreak, it raised concern imperative need developing novel effective agents to combat viral diseases now variants as well. Despite sincere concerted efforts scientists pharma giants all ...

in the past decade, a global demand for products from organic agriculture has increased rapidly. milk quality is of major interest for all parties. therefore, the objective of this study was to compare cow performance and product quality in conventional and organic system. twenty holstein dairy cows were allotted to one of 2 diet groups, which including: a conventional diet (con), and an organi...

This study reported that the sample used in was an infusion using fresh coriander leaves samples taken Lubuk Pakam area. Several studies have shown active components of seeds are essential oils such as sabiene, myrcene, alphaterpine, ocimene, linalool, graniol, decanal, desilaldehyde, trantridecen, petroselinic acid, octadesenic d-mannite, scopoletin, psimena, kamfena and felandren. These cause...