نتایج جستجو برای: anticonvulsant antitubercular

تعداد نتایج: 6799  

Journal: :Internal medicine 1993
J P Radó A Haris

The characteristics triad of tuberous sclerosis-adenoma sebaceum, mental deficiency and epilepsy-associated with distal-type renal tubular acidosis was combined with anticonvulsant osteomalacia in a 41-year-old woman. In addition to the specific bone lesions of tuberous sclerosis, the bone disease was caused by an adverse effect of a drug and possibly also by the renal disorder leading to signi...

Azadeh Yazdi Majid Hassanpour Ezzati Mohammad Sayyah, Soroush Sardari,

A review of the publications in traditional medicine indicates that the root of Glycyrrhiza glabra L., Fabaceae, is recommended for treatment of epilepsy. As a renewable source, the leaves of G. glabra var. glandulifera growing in Iran were examined for possible anticonvulsant activity. The anticonvulsant activity of the leaves’ ethanol extract and dichloromethane, f1, n-Hexane, f1A, and methan...

Journal: :Acta pharmaceutica 2003
Surendra Pandeya Anil K Agarwal Anita Singh James P Stables

A series of p-nitrophenyl substituted semicarbazones (4a-c) and phenoxy/p-bromophenoxy acetyl hydrazones (8a-q) were synthesized and their anticonvulsant activity was screened against maximal electroshock seizure (MES), subcutaneous metrazole (ScMet) and subcutaneous strychnine (ScSty) tests. Compounds 4a-c with -NHCO- were found to be the most active in all these tests. These compounds were al...

2013
Mohamed Alswah Adel Ghiaty Ahmed El-Morsy Kamal El-Gamal

2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, (1)H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized comp...

Journal: :European journal of medicinal chemistry 2012
Abraham García Virgilio Bocanegra-García Jose Prisco Palma-Nicolás Gildardo Rivera

Currently, one third of the world's population is infected with Mycobacterium tuberculosis and 8.9-9.9 million new and relapse cases of tuberculosis are reported every year. The emergence of new cases, the increased incidence of multi-drug resistant strains of M. tuberculosis, and the adverse effects of first- and second-line antituberculosis drugs have led to renewed research interest in natur...

2013
K. K. Sivakumar A. Rajasekharan R. Rao B. Narasimhan

In the present investigation, a series of 12 Mannich bases (QP1-12) and 5 Schiff bases (QSP1-5) of pyrazol-5(4H)-one moiety containing 3-(hydrazinyl)-2-phenylquinazolin-4(3H)-one has been synthesized and characterized by physicochemical as well as spectral means. The synthesized Mannich and Schiff bases were screened for their preliminary antimicrobial activity against Gram-positive and Gram-ne...

Journal: :The Egyptian Journal of Otolaryngology 2021

Abstract Background Both tonsillar tuberculosis and lichen scrofulosorum are sporadic presentations of extrapulmonary tuberculosis. Lichen commonly presents in children young adults as lichenoid eruptions over the skin. Granulomatous inflammation tonsils, however, non-specific sore throat foreign body sensation throat. The concomitant presentation abovementioned tubercular manifestations has no...

Journal: :iranian journal of basic medical sciences 0
maryam iman chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran atefeh saadabadi department of medicinal chemistry, pharmaceutical sciences branch, islamic azad university, tehran, iran asghar davood department of medicinal chemistry, pharmaceutical sciences branch, islamic azad university, tehran, iran

objective(s): recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. the ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. therefore, in the present study, a series of 19 compo...

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