نتایج جستجو برای: antagonism
تعداد نتایج: 11830 فیلتر نتایج به سال:
Orexin neuropeptides regulate sleep/wake through orexin receptors (OX1R, OX2R); OX2R is the predominant mediator of arousal promotion. The potential for single OX2R antagonism to effectively promote sleep has yet to be demonstrated in humans. MK-1064 is an OX2R-single antagonist. Preclinically, MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats a...
This experiment investigated how anonymity influenced group identification, inter-group antagonism, and attitude change in computer-mediated communication in samples of both Korean and American participants. This study also examined how self-construal moderated the effect of anonymity on intergroup antagonism. Consistent with the social identity model of deindividuation effects (SIDE), findings...
Increment threshold for a small (e.g. 1' x 5') line target superimposed on backgrounds of various shapes and sizes was measured to provide a detailed map of the spatial interactions about line targets. This modified "Westheimer paradigm" indicated sensitization in the length direction as well as in the width direction around the line target. The effect of the adaptation field summed over an elo...
Sphingosine 1-phosphate receptor 1 (S1P(1)) is a G protein-coupled receptor that is critical for proper lymphocyte development and recirculation. Agonists to S1P(1) are currently in use clinically for the treatment of multiple sclerosis, and these drugs may act on both S1P(1) expressed on lymphocytes and S1P(1) expressed within the central nervous system. Agonists to S1P(1) and deficiency in S1...
Extracts from seeds from three different varieties of grape were combined with ascorbic acid (AA) to evaluate the effects on the antiradical behaviour, using the DPPH assay. The investigations aimed at illustrating possible mixture effects, manifested either as synergism or as antagonism. By employing a simple linear regression approach, combinations of all extracts exhibited antagonism when co...
High pressure and anaesthetic agents are mutual antagonists in intact animals, but antagonism is not observed in isolated nerve cells. In order to test the hypothesis that a neural network might display pressure-anaesthetic antagonism not found in simpler systems, we have examined the effects of pentobarbitone at normal pressure and at 10.1 MPa helium pressure on the rhythmic activity of medull...
Heroin addicts consume large quantities of refined sugars. This study investigated the effect of opiate use and antagonism on sweet taste in opiate-maintained drug users and detoxified former chronic opiate users, using a within-subject design. Seven opiate users received methadone and seven buprenorphine maintenance. Six detoxified subjects received naltrexone. Sucrose recognition thresholds a...
On the dog isolated right ventricular muscle, experiments were carried out in order to elucidate the characteristics of the cholinergic antagonism against the positive inotropic action (PIA) induced via different subcellular mechanisms. The relationship between cyclic AMP and cyclic GMP levels, and contractile force during cholinergic antagonism was assessed. Carbachol (10 microM) by itself dec...
The yellow fever mosquito,Aedes aegypti, vectors disease-causing agents that adversely affect human health, most notably the viruses causing dengue and yellow fever. The efficacy of current mosquito control programs is challenged by the emergence of insecticideresistant mosquito populations, suggesting an urgent need for the development of chemical insecticides with new mechanisms of action. On...
Heart failure (HF) is an increasingly recognized complication of diabetes. Cardiac fibrosis is an important causative mechanism of HF associated with diabetes. Recent data indicate that inflammation may be particularly important in the pathogenesis of cardiovascular fibrosis. We sought to determine the mechanism by which cardiac fibrosis develops and to specifically investigate the role of the ...
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