نتایج جستجو برای: angiotensins

تعداد نتایج: 23319  

Journal: :Circulation research 1990
H Hirakata F M Fouad-Tarazi F M Bumpus M Khosla B Healy A Husain H Urata H Kumagai

We examined the hypothesis that the positive inotropic effect of angiotensin I (Ang I) may be retained in the presence of angiotensin converting enzyme inhibitors so that it may have a direct beneficial effect on the heart. Accordingly, isolated perfused hearts (Langendorff preparation) of 300-day-old cardiomyopathic hamsters (a model of spontaneous cardiomyopathy) and age-matched normal hamste...

2015
Shaaban Abdo Shao-Ling Zhang John S.D. Chan

Hyperglycemia, oxidative stress and renin-angiotensin system (RAS) dysfunction have been implicated in diabetic nephropathy (DN) progression, but the underlying molecular mechanisms are far from being fully understood. In addition to the systemic RAS, the existence of a local intrarenal RAS in renal proximal tubular cells has been recognized. Angiotensinogen is the sole precursor of all angiote...

Journal: :Clinical science 1979
D K Meyer M Eisenreich D Nutto

1. A new column-chromatographic method is described for the simple and reproducible determination of the concentration of [des-Asp1]angiotensin II (angiotensin III) in rat plasma. 2. The method uses the different abilities of the ion-exchange resins Dowex 1 (X8) and Bio Rex 70 to bind angiotensin II and angiotensin III. Under the conditions used, Bio Rex 70 binds only angiotensin III. Angiotens...

Journal: :Hypertension 1991
D Felix M C Khosla K L Barnes H Imboden B Montani C M Ferrario

The aim of this study was to investigate the action of the heptapeptide angiotensin-(1-7) on the spontaneous activity of paraventricular neurons using microiontophoresis. Recent immunocytochemical investigations have shown that this product of angiotensin I is predominantly located in cells and fibers of the forebrain and brain stem. Our results show that most neurons in the paraventricular nuc...

Journal: :Journal of the American Society of Nephrology : JASN 2004
Michel Azizi Joël Ménard Alvine Bissery Than-Tam Guyenne Alessandra Bura-Rivière Sujata Vaidyanathan Riccardo P Camisasca

Interrupting the renin-angiotensin system (RAS) with a usual daily dose of a single-site RAS inhibitor does not achieve complete and long-lasting pharmacologic blockade. Hormonal and BP effects were compared for 48 h after administration of single oral doses of 300 mg (high dose) of the renin inhibitor aliskiren (A300) and 160 mg (standard antihypertensive dose) of the AT1 receptor antagonist v...

Journal: :The Journal of biological chemistry 2003
Young June Son Min Kyu Hur Byung Jun Ryu Sang Kyu Park Giuseppe Damante Angela Valentina D'Elia Maria E Costa Sergio R Ojeda Byung Ju Lee

In recent years, it has become increasingly evident that angiotensins synthesized in the brain contribute to regulating body fluid homeostasis. Although angiotensinogen, the unique angiotensin precursor, is produced in the brain, the factors that regulate its gene expression remain unknown. We recently found that TTF-1, a homeodomain-containing transcription factor essential for the development...

Journal: :The Biochemical journal 1985
S Hedeager-Sørensen A J Kenny

Carboxypeptidase P has been purified by immunoaffinity chromatography from pig kidneys. A single-step assay with Z-Pro-Met (where Z represents benzyloxycarbonyl) as substrate was used, methionine being determined by using L-amino acid oxidase and horseradish peroxidase. The enzyme constitutes about 1.5% of the kidney microvillar proteins. Triton X-100-solubilized and papain-released forms of th...

2010
T S Mohamed Saleem K Bharani K Gauthaman

Morbidity and mortality from cardiovascular diseases are still high, even with the use of the best available therapies. There is mounting evidence that excessive renin-angiotensin system activation triggers much of the damaging and progressive nature of cardiovascular and kidney diseases through expression of angiotensin II. Moreover, angiotensin II play a major role in the development of end o...

1998
BJÖRN PLATZACK MICHAEL AXELSSON

The effects of angiotensin I, angiotensin II and exercise on ventral and dorsal aortic blood pressure and heart rate were investigated in the Atlantic cod, Gadus morhua. Both angiotensins produced a marked increase in blood pressure. After injection of the angiotensin-converting enzyme (ACE) inhibitor enalapril, both ventral and dorsal blood pressures decreased significantly and the effect of a...

Journal: :Hypertension 2000
B P Rowe B Dixon

Vasodilator and vasodepressor properties of angiotensins have been reported, and mediation by prostaglandins or nitric oxide has been proposed. Other studies indicate that angiotensin AT(2) receptors might mediate a depressor action, and the present study was designed to delineate and explore this possibility in a conscious rabbit model. Large intravenous boluses of angiotensin III (15 nmol/kg)...

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