The chemical properties of these two substances are strikingly similar. Both compounds are irreversibly decomposed under biological conditions. Alloxan has a half life of 1 minute (1) and dehydroascorbic acid has a half life of a few minutes (2). Alloxan is readily reduced to dialuric acid (3) with which it forms alloxantin (3). Dehydroascorbic acid is readily reduced to ascorbic acid (4) and a...

Diabetes mellitus (DM) is a metabolic disorder in which the carbohydrate and lipid metabolism is improperly regulated by insulin. Many indigenous Indian medicinal plants have been found to be successfully used to cure diabetes. Herbal drugs are considered to be less toxic and free from side effects than synthetic ones. Keeping this view, the study aimed to evaluate the antidiabetic and hypoglyc...

Short term effects of insulin on total brain and branchial Na+K+ ATPase, Ca2+ ATPase and Na+, K+ and Ca2+ ions were investigated in A. testudineus. The increase in brain Ca2+ ATPase after alloxan treatment may account for an increased amount of intracellular calcium required for biochemical events taking place inside the cells. Branchial Na+K+ATPase was significantly stimulated while Ca2+ ATPas...

Abstract Background Various bleaching agents are used in food industries among which some reacts to form alloxan. Therefore, the alloxan can indirectly enter a human body and thus an important aspects for studying its effect on development. In present study, of was studied climbing ability, pupation emergence flies. Fifty first instar larvae were introduced separately vials containing 0.001, 0....

BACKGROUND Diabetes has been associated with several complications occasioned by oxidative stress. Thus, in treatment of the condition, these complications must also be taken into consideration. This study evaluates the effect of Cnidoscolus aconitifolius complications of diabetes induced by alloxan, on haematology and sperm morphometry using the Wistar rats. METHODS Diabetes was induced in 2...

The chemical properties of these two substances are strikingly similar. Both compounds are irreversibly decomposed under biological conditions. Alloxan has a half life of 1 minute (1) and dehydroascorbic acid has a half life of a few minutes (2). Alloxan is readily reduced to dialuric acid (3) with which it forms alloxantin (3). Dehydroascorbic acid is readily reduced to ascorbic acid (4) and a...

Streptozotocin and alloxan were administered to Wistar rats in combination with poly(adenosine diphosphate ribose) synthetase inhibitors. Ten to 16 months after the injection of streptozotocin (50 mg/kg body weight i.v.) and 3-aminobenzamide (345 mg/kg i.v.), streptozotocin (50 mg/kg) and nicotinamide (350 mg/kg i.p.), streptozotocin (50 mg/kg) and picolinamide (250 mg/kg i.p.), alloxan (40 mg/...

An early event in the induction of apoptosis is cytochrome c (Cyt c) release from mitochondria. We investigated the involvement of mitochondrial permeability transition (MPT) and mitochondrial swelling in Cyt c release from mitochondria treated with alloxan and/or calcium (Ca). When mitochondria were treated with a high concentration of Ca alone or Ca with alloxan (alloxan-Ca), the MPT was acco...

Sweet potatos rood contain lots of beta-carotene, polyphenols and flavonoids. Alloxan proven pancreatic cell damage through oxidative stress mechanisms. The compound beta-carotene, polyphenols and flavonoids are thought to antioxidative and cytoprotective, inhibit cell damage caused by alloxan exposure. This study aimed to determine the effect of ethanolic extract of sweet potatos (Ipomoea bata...

A characteristic alteration of hepatic glycogen content by fasting was analyzed about alloxan diabetic rats. 1) In the fed state, hepatic glycogen content was suppressed in alloxan diabetic rats. However, when rats were fasted for 48 hours hepatic glycogen content was higher in alloxan diabetic rats than in the normal ones. There was a positive correlation between the blood glucose level and th...