chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. in the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and wistar rats by using the writhing and formalin-induced paw edema tests respectively. the activities of the compounds were compared with celecoxib as a referenc...

in some special cases, rubber compounds with high amounts of unsaturated elastomer are recommended with organic sulfur donors instead of mineral sulfurs. in this condition, activated sulfur is produced in situ and curingprocess is facilitated without accelerators. organic sulfur donor compounds have low thermal stability and in the vulcanization temperature produce free and activated sulfurs. t...

Background and aim: Extraction of natural antioxidant compounds has recently attracted the attention of researchers. Almond is one of the native products of  Iran, which annually during the process of production , large volumes of waste is achieved. The aim of this study is investigating the impact of two parameters (time and ethanol percentage) on the extraction of phenol and ...

Pyrido- and pyrrolo[2,3-d]oxazoles can be conveniently prepared in high yield from the Ritter reaction of nitriles and in situ generated chiral cyclic N-acyliminium ions. cis-4-Hydroxy-5-acylaminopyrrolidines and cis-5-hydroxy-6-acylaminopiperidines can be readily obtained by acid hydrolysis of these bicyclic heterocyclic compounds, respectively.

Chiral N-heterocyclic carbenes were found to be efficient catalysts for the formal [2+2] cycloaddition reaction of alkyl(aryl)ketenes and nitroso compounds to give the corresponding 1,2-oxazetidin-3-ones in moderate to good yields with high enantioselectivities. Reductive ring-opening of the oxazetidinones give the corresponding α-hydroxy acid derivatives in good yields.

a new series of thiazolidinedione derivatives were synthesized. the structures of these compounds were established by means of ir, 1h-nmr and elemental analysis. all of the compounds were screened for antidiabetic activity on albino rats. most of the compounds showed significant antidiabetic activity when compared with the standard drug glibenclamide.