ns-Diamminedichloroplatinum(II) is the first of a group of platinum coordination complexes with antineoplastic ac tivity to be studied in humans. This Phase I investigation characterizes the toxicity and pharmacological disposition of the drug in 10 patients. Plasma levels of m-diamminedichloroplatinum(II) decayed in a biphasic mode, with an initial half-life of 25 to 49 min and a secondary pha...

Since the establishment of all-trans retinoic acid (ATRA) differentiation therapy, the prognosis of acute promyelocytic leukemia (APL) has improved, and APL has become a curable subtype of acute myelocytic leukemia. Complete remission can be achieved with ATRA alone, but disease-free survival is still too short because of relapse. To overcome this drawback, ATRA has been used in combination wit...

By CHARLES P. DUVALL, PAUL P. CARBONE, WILLIAM R. BELL, JACQUEUNE WILANG, J. H. TJI0 AND SEYMOUR PERRY A MINOR DEGREE OF LYMPHADENOPATHY occurs in relatively few cases of patients with chronic myelocytic leukemia ( CML ).‘ Marked lymph node enlargement may occur late in the course of the disease, usually with the development of the myeloblast crisis, and may be considered a poor prognostic sign...

Chronic myelocytic leukemia (CML)' is a clonal pluripotent stem cell disease, clinically divided into a chronic phase of a median duration of ^-4 yr, followed by an acute phase (blast crisis) lasting for few months (1) . Cytogenetic hallmark of most (95%) CML cases is the presence of the Philadelphia (Ph) chromosome, resulting from a reciprocal translocation between chromosomes 9 and 22 (2, 3) ...

The biochemical and pharmacological effects oÃEscherichia coli asparagjnase were studied in 45 patients with leukemia and solid tumors. The drug was given in three different schedules: as a single dose, daily, or weekly. After i.v. injec tion, the peak activity obtained was dose related; the initial clearance of the enzyme from plasma followed first-order kinetics, and a half-life was about 14 ...

Seventy five radiation-related leukemias (acute non-lymphocyte) in Hiroshima including 16 patients exposed to more than one Gray were cytogenetically examined. Statistical analysis of the data on the frequencies of chromosomal aberrations in survivors according to the bone marrow doses of DS86 estimation revealed that heavily exposed patients tended to have significantly higher aberration rates...

The biochemical and pharmacological effects oÃEscherichia coli asparagjnase were studied in 45 patients with leukemia and solid tumors. The drug was given in three different schedules: as a single dose, daily, or weekly. After i.v. injec tion, the peak activity obtained was dose related; the initial clearance of the enzyme from plasma followed first-order kinetics, and a half-life was about 14 ...

Consecutive studies of timed sequential therapy were conducted in 44 adults with acute myelocytic leukemia. The rationale was based on evidence that bone marrow prolifer ation in vivo relates temporally to induced humoral stimu latory activities, and on models that demonstrate increased cytotoxicity of cytosine arabinoside to myeloblasts cultured in stimulatory serum. In the initial study (26 p...

DNA samples from patients with chronic lymphocytic (CLL), chronic myelocytic (CML), acute myelocytic (AML), and acute lymphocytic leukemia (ALL), as well as samples from patients with multiple myeloma (MM) and healthy volunteers, were analyzed for their genomic methylation status using Hpa II and Msp I digestions followed by a simple gel electrophoresis and ethidium bromide staining. A densitom...