The clinical and pathological features of 63 cases of post-mortem-proved diffuse infiltration of the leptomeninges by tumour are presented. A wide variety of tumours of the nervous system, both primary and secondary, was found to give rise to such involvement, with adenocarcinoma having a particular propensity to behave in this manner. Dysfunction of cranial and spinal nerves, a confusional sta...

The aim of this exploratory study was to examine the relationship of electroencephalogram (EEG) arousals to breathing patterns and the relationship of both arousals and breathing patterns to arterial oxygenation during sleep in older adults. Five older adults were monitored using standard polysomnography. Records were divided into 5-min segments and breathing patterns identified based on the le...

OBJECTIVE To examine cognitive activity limitations and predictors of outcome 1 year post-trauma in patients admitted to sub-acute rehabilitation after severe traumatic brain injury. SUBJECTS The study included 119 patients with severe traumatic brain injury admitted to centralized sub-acute rehabilitation in the Eastern part of Denmark during a 5-year period from 2005 to 2009. METHODS Leve...

All patients were women over the age of 80 years and were treated with benoxaprofen 600 mg daily. Case 1-An 86-year-old woman presented in January 1981 with a confusional state. She had a smooth firm liver palpable 6 cm below the costal margin, erythrocyte sedimentation rate of 75 mm in first hour, and a slightly raised alkaline phosphatase activity. She recovered spontaneously and was not seen...

Non-convulsive confusional status epilepticus (NCSE) is clinically characterized by prolonged impairment of consciousness of variable entity, often associated with myoclonias or automatisms. EEG shows continuous paroxysmal activity or electrographic discharges. When NCSE occurs in older patients, differential diagnosis with other conditions such as stroke or toxic/metabolic encephalopathy, may ...

A 75-year-old woman was admitted with febrile confusion and abdominal pain. She was taking medications that included lanthanum carbonate. Examination, biology, a cerebral scan, and a review of her medications could not explain the confusion. The plain film of the abdomen revealed multiple diffuse calcium-like deposits throughout the digestive tract. The plasma levels of lanthanum were higher th...

People who have epilepsy seem particularly liable to certain major psychiatric disorders: a chronic interictal psychosis that closely resembles schizophrenia; and episodic psychotic states, some of which may arise in close temporal relation with seizure activity. These disorders are conventionally referred to as the psychoses of epilepsy although some of the episodic forms would be more accurat...

People who have epilepsy seem particularly liable to certain major psychiatric disorders: a chronic interictal psychosis that closely resembles schizophrenia; and episodic psychotic states, some of which may arise in close temporal relation with seizure activity. These disorders are conventionally referred to as the psychoses of epilepsy although some of the episodic forms would be more accurat...

INTRODUCTION Methoxphenidine is a novel dissociative designer drug of the diarylethylamine class which shares structural features with phencyclidine (PCP), and is not at present subject to restrictive regulations. There is very limited information about the acute toxicity profile of methoxphenidine and the only sources are anonymous internet sites and a 1989 patent of the Searle Company. We rep...