SUMMARY DNA methylation is a major epigenetic modification in human cells. Illumina HumanMethylation27 BeadChip makes it possible to quantify the methylation state of 27 578 loci spanning 14 495 genes. We developed a non-parametric normalization method to correct the spatial background noise in order to improve the signal-to-noise ratio. The prediction performance of the proposed method was ass...

1. Wiestner A, Cho HJ, Asch AS, et al. Rituximab in the treatment of acquired factor VIII inhibitors. Blood. 2002;100:3426-3428. 2. Kain S, Copeland T-S, Leahy MF. Treatment of refractory autoimmune (acquired) haemophilia with anti-CD20 (rituximab) (letter). Brit J Haem. 2002;119: 578. 3. Stasi R, Pagano A, Stipa E, Amadori S. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult...

Methods: The study was based on 768 failed primary TKAs revised to TKAs (TKA/TKA) and 578 failed primary UKAs revised to TKAs (UKA/TKA) reported to the Norwegian Arthroplasty Register between 1994 and 2011. Patient-reported outcomemeasures (PROMs) including the EuroQol EQ-5D, the Knee Injury and Osteoarthritis Outcome Score (KOOS), and visual analog scales assessing satisfaction and pain were u...

I present a new compilation of the distribution of the temporal distribution of new morphologies of marine invertebrates associated with the Ediacaran-Cambrian (578-510 Ma) diversification of Metazoa. Combining this data with previous work on the hierarchical structure of gene regulatory networks, I argue that the distribution of morphologies may be, in part, a record of the time-asymmetric gen...

A checklist of Heteroptera type specimens deposited in the collection of División Entomología, Museo de La Plata. It harbours type material of 1153 species belonging to 37 families (Enicocephalidae, Schizopteridae, Gerridae, Veliidae, Hydrometridae, Naucoridae, Belostomatidae, Nepidae, Corixidae, Notonectidae, Pleidae, Saldidae, Cimicidae, Polyctenidae, Nabidae, Miridae, Tingidae, Vianaididae, ...

El delito de exaltación del terrorismo o los terroristas, contenido en el art. 578 Código Penal español, castiga dos tipos conducta: la terrrorismo humillación sus víctimas. Tribunal Supremo español lo ha entendido modos diferentes su jurisprudencia: como una (mera) ofensa riesgo un daño futuro. Se argumenta con frecuencia que este implica discurso odio. Este ensayo trata mostrar que, mientras ...

Se evaluó el efecto de la suplementación con harina mashua (Tropaeolum tuberosum) y tarwi (Lupinus mutabilis) sobre ganancia peso vivo (GPV), consumo alimento, índice conversión alimenticia composición nutricional carcasas cuyes raza Perú. utilizaron 32 machos 4 semanas edad (309-578 g) distribuidos aleatoriamente en cuatro tratamientos (T) durante 40 días: T1 (concentrado integral - CI), T2 (C...

This article quantifies the value of U.S. highways. We develop a multisector general equilibrium model with many locations in United States (i.e., counties) and countries. In model, producers choose shipping routes subject to domestic international trade costs, endogenous congestion, port efficiency at transshipment points. Applying we find that removing Interstate Highway System reduces real G...

A new doubling algorithm – Alternating-Directional Doubling Algorithm (ADDA) – is developed for computing the unique minimal nonnegative solution of an M -Matrix Algebraic Riccati Equation (MARE). It is argued by both theoretical analysis and numerical experiments that ADDA is always faster than two existing doubling algorithms – SDA of Guo, Lin, and Xu (Numer. Math., 103 (2006), pp. 393–412) a...