The FABGL gene encodes a nicotinamide adenine dinucleotide (NAD)-dependent 17β-hydroxysteroid dehydrogenase (17b-HSD) which is responsible mainly for immune response. It can also regulate the concentration of biologically active estrogens and androgens. It is appear as oxidative enzyme that inactivates estradiol, testosterone, and dihydrotestosterone as well as reductive enzyme by synthesis of ...

Sulfate esters of steroid hormones had been considered to represent end products of steroid metabolism designed for excretion. Sulfation of steroids in vitro had been demonstrated with mammalian liver preparations, and it had been generally assumed that the liver was the major site of production of these compounds in man. Revision of this view became necessary with the demonstration that the st...

ents near these stations become increasingly steep. The generalized skew map selected for this study was based on a grid spacing of 20,000 meters and 12 stations. The part of the map for western Oregon is shown in figure 8. This map was selected because it had the smallest mean square error while having skew isolines that are smooth and with no peaks or valleys. This map offers considerable imp...

This study confirms previous reports that satisfactory gastric acid secretory responses to intravenous administration of histamine, carbachol, and gastrin can be obtained. Bilateral castration of the male rats significantly reduced acid gastric secretory responses to carbachol but not to histamine. Overiectomized rats treated with 17B-oestradiol (short-term treatment) showed a statistically sig...

Human Immunodeficiency Virus (HIV) infection is initiated by binding of the viral glycoprotein gp120, to the cellular receptor CD4. On CD4 binding, gp120 undergoes conformational change, permitting binding to the chemokine receptor. Crystal structures of gp120 ternary complex reveal the CD4 bound conformation of gp120. We report here the application of the Gaussian network model (GNM) to the cr...

Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defens...

Bisphenol A (BPA) has lower estrogenic potency than 17b-estadiol. The reference dose of BPA is defined as 50 ug/kg bw/day by the Environmental Protection Agency. The lower doses of BPA than no observable effect level are considered safe. However, early life exposure to low-dose BPA may increase the risk of developing adult onset disease. The harmful effects caused by low-dose BPA in fetus and n...