changes of intracranial pressure due to some curative and hygienic activities   a. mahmoodi rad msc1, m. foroozi msc2*, s. mohamad alizaheh msc3   1- academic member, school of nursing, lar, iran   2- academic member, school of nursing and midwifery, kerman, iran   3- academic member, school of nursing and midwifery, kerman, iran   background: evaluation the patients for determining the sings o...

This study deals with Bohemian and Moravian students at five Reformed institutes of higher learning in the territory current Germany Switzerland period 1575–1620. In particular, it traces their presence universities Basel, Heidelberg, Marburg, academies Herborn Geneva. Each selected institutions is introduced a cameo, which addition to brief history school mentions also most important professor...

The endothelins (ET) have been implicated in vasopressin (AVP) release in vivo and in vitro. The effects of ET in this system are complex, and the net AVP secretory response likely depends on a unique combination of ET isoform, ET receptor subtype, and neural locus. The purpose of these studies was to examine the role of ET receptor subtypes at hypothalamic vs. neurohypophysial sites on somatod...

Production of reactive oxygen species (ROS) may be increased during hypoxia in pulmonary arteries. In this study, the role of ROS in the effect of hypoxia on endothelin (ET) type B (ETB) receptor-mediated vasocontraction in lungs was determined. In rat intrapulmonary (approximately 0.63 mm ID) arteries, contraction induced by IRL-1620 (a selective ETB receptor agonist) was significantly attenua...

In freshly isolated rabbit pulmonary artery smooth muscle cells, endothelin (ET)-1 induced a transient increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) followed by a return to the initial [Ca(2+)](i). This response was not abolished by the voltage-dependent Ca(2+) channel blocker nicardipine or removal of Ca(2+) from the bath solution but was inhibited by ryanodine and thapsigargin....

We previously reported that endothelin (ET) 3 inhibited presynaptically the dog stellate ganglionic transmission. Here, we report the investigation of the possible involvement of nitric oxide pathway in the endothelin-induced inhibition of the ganglionic transmission. The amount of acetylcholine released by preganglionic stimulation for 10 min was concentration-dependently inhibited after expos...

AIMS The aim of the present study was to elucidate the molecular mechanism underlying the concomitant occurrence of cardiac conduction disease and long QT syndrome (LQT3), two SCN5A channelopathies that are explained by loss-of-function and gain-of-function, respectively, in the cardiac Na+ channel. METHODS AND RESULTS A Caucasian family with prolonged QT interval, intermittent bundle-branch ...

Las relaciones entre Lope de Vega y Calderón la Barca, los dos máximos dramaturgos españoles del Siglo Oro, cuya actividad literaria coincidió en el período 1620-1635, resultan gran interés para crítica, pues inciden tanto ámbito personal público como estrictamente literario. El presente artículo analiza ecos comedia ¡Ay, verdades, que amor...!, estrenada 1626, astrólogo fingido, Calderón, escr...

Binding and functional studies were conducted to elucidate the receptor subtypes mediating contractions of human bronchus induced by endothelin (ET) receptor ligands. Binding experiments in human bronchial smooth muscle membrane preparations revealed the presence of ETA and ETB receptors in the ratio of approximately 40:60. In the presence of the combination of 1 microM BQ-123 (ETA receptor ant...