The clinical value of imaging is well established for the follow-up of many lymphoid malignancies but not for chronic lymphocytic leukemia (CLL). A meta-analysis was performed with the dataset of 3 German CLL Study Group phase 3 trials (CLL4, CLL5, and CLL8) that included 1372 patients receiving first-line therapy for CLL. Response as well as progression during follow-up was reassessed accordin...

The chemokine stromal cell–derived factor-1 (SDF-1) is constitutively expressed by bone marrow stromal cells and plays key roles in hematopoiesis. Fibroblast growth factor 2 (FGF2), a member of the FGF family that plays important roles in developmental morphogenic processes, is abnormally elevated in the bone marrow from patients with clonal myeloid disorders and other disorders where normal he...

Previous reports from this laboratory (van Golde, L. M. G., Schulman, H., and Kennedy, E. P. (1973) Proc. N&l. Acad. Sci. U. S. A. 70, 1368-1372; Kennedy, E. P., Rumley, M. K., Schulman, H., and van Golde, L. M. G. (1976)J. Biol. Chem. 251, 4208-4213) described the discovery in Escherichia coli of a novel class of glucose-containing oligosaccharides (“the membrane-derived oligosaccharides”) var...

Adhesion to the microenvironment profoundly affects stem cell functions, including proliferation and differentiation, and understanding the interaction of stem cells with the microenvironment is important for controlling their behavior. In this study, we investigated the effects of the integrin binding epitopes GFOGER and IKVAV (natively present in collagen I and laminin, respectively) on human...

Environmental, developmental and genetic factors affect variation in wood properties at the chemical, anatomical and physical levels. Here, the phenotypic variation observed along the tree stem was explored and the hypothesis tested that this variation could be the result of the differential expression of genes/proteins during wood formation. Differentiating xylem samples of maritime pine (Pinu...

BACKGROUND A real-time electronic predictive model that identifies hospitalized heart failure (HF) patients at high risk for readmission or death may be valuable to clinicians and hospitals who care for these patients. METHODS An automated predictive model for 30-day readmission and death was derived and validated from clinical and nonclinical risk factors present on admission in 1372 HF hosp...

Language tests developed and validated in one country may lose their desired properties when translated for use in another, possibly resulting in misleading estimates of ability. Using Item Response Theory (IRT) methodology, we assess the performance of a test of receptive vocabulary, the U.S.-validated Peabody Picture Vocabulary Test-Third Edition (PPVT-III), when translated, adapted, and admi...

La figura de la frustración del fin contrato resulta ser interesante, pues pone en jaque al principio pacta sunt servanda, propio civil law que vendría a nuestra familia jurídica. En el Perú, está no actualmente recogida legislación. No obstante, año 2019, se presentó una primera propuesta regulación artículo 1372-A Anteproyecto reforma Código Civil peruano, lo evidenciaría importancia dicha es...

Abstract We present a novel method for mixed-integer optimization problems with multivariate and Lipschitz continuous nonlinearities. In particular, we do not assume that the nonlinear constraints are explicitly given but can only evaluate them know their global constants. The algorithm is successive linear relaxation in which alternate between solving master problem, of original subproblem, de...