Recently, a novel CS/DS 4-O-endosulfatase was identified from marine bacterium and its catalytic mechanism investigated further (Wang, W., et. al (2015) J. Biol. Chem.290, 7823–7832; Wang, S., (2019) Front. Microbiol.10, 1309). In the study herein, we provide new insight about structural characteristics of substrate which determine activity this enzyme. The specificities were probed by using li...

Consider a Bertrand model in which each rm may be inactive with a known probability, so the number of active rms is uncertain. This activity level can be endogenized in any of several ways{ as whether to incur a xed cost of activity, as output choice, or as quality choice. Our model has a mixed-strategy equilibrium, in which industry pro ts are positive and decline with the number of rms, the s...

Factors influencing the labelling of rhinitis by doctors were examined in 7702 adults, aged 16-65 years, registered with a group general practice in south London. Individuals with rhinitis were identified by a postal screening questionnaire. Of the 2969 (39%) subjects who replied, 1309 (44%) reported rhinitis. A sample of 340 individuals with and 126 without rhinitis was studied, each being int...

Inactivation of the adenomatous polyposis coli (APC) gene product initiates colorectal tumorigenesis. Patients with familial APC (FAP) carry germ-line mutations in the APC gene and develop multiple colorectal adenomas and subsequent carcinomas early in life. The severity of the disease correlates with the position of the inherited APC mutation (genotype-phenotype correlation). Together with the...

OBJECTIVE The main objective was to compare the cost-effectiveness of therapeutic options in moderate or severe rheumatoid arthritis (RA) when a clinical response to a first TNF-blocker, either etanercept (ETA), adalimumab (ADA), or infliximab (INF), is insufficient. METHODS Effectiveness criteria were defined as remission (RS), low disease activity (LDAS), and moderate to high disease activi...

Preliminary palaeomagnetic data are presented for the AND-1B drill core. A total of 1309 samples were collected from the drill core immediately following recovery and splitting. Natural remanent magnetisation (NRM) and bulk magnetic susceptibility data were determined for all samples using a Molspin spinner magnetometer and Bartington Instruments susceptibility bridge, respectively, immediately...

HALL, RODNEY C., AND ROBERT L. HODGE. Changes in catecholamine and angiotensin levels in the cat and dog during hemorrhage. Am. J. Physiol. 221(5) : 1305-1309. 197 1 .-The changes in the circulating levels of catecholamines and angiotensin were estimated simultaneously in cats and dogs during two different rates of hemorrhage to a constant volume by using an especially developed bioassay techni...

CONTEXT The duration of protection from tuberculosis of BCG vaccines is not known. OBJECTIVE To determine the long-term duration of protection of a BCG vaccine that was previously found to be efficacious. DESIGN Retrospective record review using Indian Health Service records, tuberculosis registries, death certificates, and supplemental interviews with trial participants. SETTING AND PART...

consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 1999;42:1309–11. 2. Sanna G, Bertolaccini ML, Cuadrado MJ, Khamashta MA, Hughes GR. Central nervous system involvement in the antiphospholipid (Hughes) syndrome. Rheumatology 2003;42:200–13. 3. Brey RL, Abbott RD, Curb JD et al. Beta 2-glycoprot...

The motion of the free surface of an ideal fluid under the effects of gravity and capillarity arises in a number of problems of practical interest (e.g. open-ocean pollutant transport, deep-sea oil platform design, and the generation and propagation of tsunamis), and, consequently, the reliable and accurate numerical simulation of these “water waves” is of central importance. In a pair of recen...