نتایج جستجو برای: 1294
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OBJECTIVE To analyse the effect of a fetal surveillance unit, which undertakes a wide range of maternal and fetal tests on an outpatient or inpatient basis, on the number and length of antenatal hospital admissions. DESIGN A comparison of the number and length of antenatal admissions six months before and five months after the opening of the unit on 1 July 1990. MAIN OUTCOME MEASURES Admiss...
OBJECTIVE To determine whether there is an independent association between infection with Chlamydia pneumoniae and ischaemic heart disease. DESIGN Prospective study using a nested case-control design. SETTING Medical centre in London run by BUPA, a private medical organisation. PARTICIPANTS 21 520 professional men aged 35-64 who attended for a medical examination in London between 1975 an...
Introduction In his study of the didactic origins of chemistry Owen Hannaway maintained that in the seventeenth century chemistry achieved ‘sufficient coherency and identity to sustain a vigorous and ongoing didactic tradition.’ The origins of the debate on the status of alchemy can be traced back to the Middle Ages. Albert the Great (1206-1280) and Roger Bacon (c. 1214-1294) maintained that al...
Fourier Transform Infrared (FTIR) spectroscopy is a label free methodology showing promise in characterizing different types of cell death. Cervical adenocarcinoma (HeLa) and African monkey kidney (Vero) cells were treated with a necrosis inducer (methanol), novel apoptotic inducers (diphenylphosphino gold (I) complexes) and positive control, auranofin. Following treatment, cells stained with a...
A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with the luminal domain (LD) of its neuronal receptor SV2C revealed only few speci...
Helicobacter pylori colonizes the gastric mucosa of half of the human population, causing gastritis, ulcers, and cancer. H. pylori is naturally competent for transformation by exogenous DNA, and recombination during mixed infections of one stomach with multiple H. pylori strains generates extensive allelic diversity. We developed an in vitro transformation protocol to study genomic imports afte...
Aripiprazole is a novel atypical antipsychotic for the treatment of schizophrenia. It is a D2 receptor partial agonist with partial agonist activity at 5-HT1A receptors and antagonist activity at 5-HT2A receptors. The long-term efficacy and safety of aripiprazole (30 mg/d) relative to haloperidol (10 mg/d) were investigated in two 52-wk, randomized, double-blind, multicentre studies (using simi...
BACKGROUND Recent experimental and epidemiological findings suggest that some infectious agents play a role in the development and promotion of atherosclerosis. We have investigated the possible association between hepatitis B virus surface antigen (HBsAg) positivity and carotid arteriosclerosis. METHODS AND RESULTS In this cross-sectional cohort study, we analyzed data from subjects undergoi...
Genome-wide association studies (GWAS) have proven highly successful in identifying single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. The majority of these studies are on European populations, with limited SNP association data in other populations. We genotyped 51 GWAS-identified SNPs in two independent cohorts of Singaporean Chinese. Cohort 1 comprised 1294 BC cas...
Amaç: Bu çalışmanın amacı ʿAlī b. el-ʿAbbās el-Mecūsī’nin Kāmilu’ṣ-Ṣınāʿati’ṭ-Ṭıbbiyye adı verilen eserinin ikinci cildinin “hastalıkların el ile tedavisi” üzerine olan dokuzuncu makalesinin kan alma ilgili bölümünü Arapçadan Türkçeye çevirerek Türk tıp tarihi literatürüne kazandırmak, Paulus Aegineta’nın Epitome adlı bölümüyle karşılaştırmak ve literatür eşliğinde tarihindeki yerini belirlemey...
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