Recent progress in identification and mapping of single nucleotide polymorphisms (SNPs) in the human genome generates an unprecedented opportunity to explore cause-effect relationships between genetic variations and susceptibility to common diseases. For this purpose, one promising strategy would be to select a set of SNPs that potentially alter the function of proteins involved in the pathogen...

Theessen H, Karakaya M, Daniel WG, Bautz W, Kalender WA, Anders K. Contrast-enhanced coronary artery visualization by dual-source computed tomography–initial experience. Eur J Radiol 2006;57:331–335. 9. Johnson TR, Nikolaou K, Wintersperger BJ, Leber AW, von Ziegler F, Rist C, Buhmann S, Knez A, Reiser MF, Becker CR. Dual-source CT cardiac imaging: initial experience. Eur Radiol 2006;16:1409–14...

Publications 1. Merucci P., Taggi F., Marolla A., Abbolito M.R., Vitelli G., Marolla P., Meliffi L., Chiarotti F., Menniti Ippolito F., Ameglio F. (1984). “Disciminant Analysis of Hodgkin's disease and non-Hodgkin's Lymphomas by Age and Serum Proteins”. European Journal of Cancer and Clinical Oncology, Vol. 20(10), pp. 1243-1247. 2. Chiarotti F., Alleva E., Bignami G. (1987). “Problems of test ...

Immune thrombocytopenia (ITP) is a bleeding disorder characterized by antibodyopsonized platelets being prematurely destroyed in the spleen, although some patients with ITP may have a cell-mediated form of thrombocytopenia. Although several animal models of ITP have been developed, few mimic primary chronic ITP nor have any shown cell-mediated platelet destruction. To create this type of model,...

This study aims to identify the crucial miRNAs in Epstein-Barr virus-positive nasopharyngeal carcinoma (NPC) and their target genes. Gene expression profile data (GSE12452) that included 31 NPC and 10 normal nasopharyngeal tissue specimens were downloaded. Differentially expressed genes (DEGs) were identified using significance analysis of microarrays. The underlying function of DEGs was predic...

OBJECTIVE To examine the outcomes of an unwanted first pregnancy (abortion v live delivery) and risk of depression and to explain discrepancies with previous research that used the same dataset. DESIGN Longitudinal cohort study. SETTING Nationally representative sample of US men and women aged 14-24 in 1979. PARTICIPANTS 1247 women in the US national longitudinal survey of youth who abort...

When a single brief visual flash is accompanied by two auditory bleeps, it is frequently perceived incorrectly as two flashes. Such illusory multisensory perception is associated with increased activation of retinotopic human primary visual cortex (V1) suggesting that such activity reflects subjective perception [Watkins, S., Shams, L., Tanaka, S., Haynes, J.D., Rees, G., 2006. Sound alters act...

Little is understood about the relationship between therapist competence and the outcome of patients treated for common mental health disorders. Understanding the relationship between competence and patient outcome is of fundamental importance to the dissemination and implementation of Cognitive Behavioural Therapy (CBT). The current study extends existing literature by exploring the relationsh...

OBJECTIVE To determine whether a moral reasoning exercise can improve response quality to surveys of healthcare priorities METHODS A randomised internet survey focussing on patient age in healthcare allocation was repeated twice. From 2574 internet panel members from the USA and Canada, 2020 (79%) completed the baseline survey and 1247 (62%) completed the follow-up. We elicited respondent pre...

IL-27 could inhibit the development of Th17 cells, and the Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim of this study was to investigate the association between genetic polymorphisms in IL27 with PE. Three SNPs in IL27 (rs153109, rs17855750, and rs181206) were genotyped in a Chinese Han cohort of 1040 PE patients and 1247 normal pregnant women u...