The expression of MDR1b coding mRNA is increased in alveolar type II cells from juvenile rat lung in culture. Hydrogen peroxide and paraquat-induced further upregulation supporting that oxidative stress mediated mechanisms are involved in the regulation of MDR1b in rat lung. The expression rates of mRNA for catalase, Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and Mn-superoxide dismutase (Mn-SOD) re...

Haemophilus ducreyi produces a periplasmic copper-zinc superoxide dismutase (Cu-Zn SOD), which is thought to protect the organism from exogenous reactive oxygen species generated by neutrophils during an inflammatory response. We had previously identified the gene, sodC, responsible for the production and secretion of Cu-Zn SOD and constructed an isogenic H. ducreyi strain with a mutation in th...

The superoxide anion ([Formula: see text]) appears to be an important modulator of nitric oxide (NO ⋅) bioavailability. The present study was designed to characterize the role of copper/zinc superoxide dismutase (Cu/Zn SOD) in endothelium-dependent relaxations. Cu/Zn SOD was inhibited with the Cu2+chelator diethyldithiocarbamic acid (DETCA). In isolated canine basilar arteries, DETCA (7.6 × 10-...

The title zinc amide, [Zn(C12H21N2Si)2], was prepared by the metathetical reaction of [LiN(SiMe2NEt2)(C6H5)]2 with zinc dichloride. It is mononuclear and the mol-ecule is generated by twofold rotation symmetry. The central Zn(II) atom is N,N'-chelated by each of the two N-silylated anilide ligands in a highly distorted tetra-hedral environment. Two N-Si-N ligands are arranged in a cis fashion a...

Superoxide dismutases (SODs) and superoxide radicals in peroxisomes Peroxisomes are subcellular respiratory organelles that contain catalase and H202-producing flavin oxidases as basic enzymatic constituents [1,2]. In recent years, it has become increasingly clear that peroxisomes carry out essential functions in almost all eukaryotic cells [3-51, and an important characteristic of peroxisomes ...

A small amount of Zn impregnated by ALD triggered enhancement of the mechanical as well as electrical properties of the graphene oxide (GO) membrane. In addition, the Zn-impregnated membranes selectively separated diverse organic vapors while maintaining high water permeability.

Understanding Zn uptake dynamics is critical to rice grain Zn biofortification. Here we examined soil Zn availability and Zn uptake pathways as affected by genotype (high-grain Zn varieties IR69428 and IR68144), Zn fertilization and water management in two pot experiments. Results showed significant interactions (P < 0.05) between genotypes and Zn fertilization on DTPA (diethylenetriaminepentaa...

Objective(s): to investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. Materials and Methods: Fifty male Wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn sup...

Since oxygen appeared in the biosphere some 3–5 billion years ago, all organisms have had to deal with the hazards of potentially damaging reactive oxygen species (ROS), such as superoxide, hydrogen peroxide, and hydroxyl radical. Like all organisms, pathogenic microbes produce ROS as byproducts of aerobic metabolism, but the burden of ROS is magnified when these microbes confront the oxidative...

The increase in brain levels of chelatable zinc (Zn) in dysfunctions involving oxygen deprivation has stimulated the treatment with Zn chelators, such as diethyldithiocarbamate (DEDTC). However, DEDTC is a redox-active compound and it should be better evaluated during hypoxia. We use the hypoxia model in zebrafish to evaluate DEDTC effects. The exploratory behavior, chelatable Zn content, activ...