pegylated polypropyleneimine (ppi) dendritic scaffold was used for the delivery of an anti-leukemic drug, imatinib. the current study evolves and emerges the use pegylated ppi dendritic scaffold for the delivery of this drug. in this imatinib was synthesized and loaded with pegylated ppi dendritic scaffold. parameters such as ft-ir, nmr, sem, drug release, dsc and hemolytictoxicity are required...

objective:more similarity to in vivo medium may help to increase the proliferation and differentiation of cells at in vitro condition. the present study has investigated the effect of a dynamic mediumand nano hydroxyapatite (nha) presence on proliferation and differentiation of mesenchymal stem cells (mscs) to bone cells using electrospun polycaprolactone (pcl) scaffolds. methods: we prepared p...

Proteins with multiple binding sites play important roles in cell signaling systems by nucleating protein complexes in which, for example, enzymes and substrates are co-localized. Proteins that specialize in this function are called by a variety names, including adapter, linker and scaffold. Scaffold-mediated nucleation of protein complexes can be either constitutive or induced. Induced nucleat...

Vascularization is a key issue for the success of tissue engineering to repair damaged tissue. In this study, we report a composite scaffold delivering angiogenic factor for this purpose. Vascular endothelial growth factor (VEGF) was loaded on mesoporous silica nanoparticle (MSN), which was then incorporated within a type I collagen sponge, to produce collagen/MSN/VEGF (CMV) scaffold. The CMV c...

We report the fabrication of a coaxial electrospun scaffold with bioactive molecule in core and protein conjugated at surface. To construct scaffold, we chose polyethylene oxide for material polycaprolactone/Jeffamine blend shell.

the aim of this study was to investigate the interactions between rat intestine decellularized scaffold and human adipose derived mesenchymal stem cells. rat large intestine was dissected in fragments and decellularized by physicochemical methods. the scaffolds were loaded by human adipose derived mesenchymal stem cells expressing green fluorescent protein. microscopic sections were prepared fr...

background: spinal cord has a limited capacity to repair therefore, medical interventions are necessary for treatment of injuries. transplantation of schwann cells has shown a great promising result for spinal cord injury (sci). however, harvesting schwann cell has been limited due to donor morbidity and limited expansion capacity. furthermore, accessible sources such as bone marrow stem cells ...

background a potential treatment for healing hepatic tissue is delivering isolated hepatic cells to the site of injury to promote hepatic cells formation. in this technology, providing an appropriate injectable system for delivery of hepatic cells is an important issue. in this regard, fibrin scaffolds were designed with many advantages over other scaffolds like cell delivery vehicles for biode...